Evidence map›Paper›PMID 42268342›Full record

ArticleApplied biochemistry and biotechnology2026

Decreasing S1PR3 Alleviated Renal Tubular Lipid Deposition in Diabetic Nephropathy via AMPK/PPAR-γ/GPAT3 Pathway.

Xiaohui Wang, Jian Teng, Zhenzhen Yu, Ying Sun, Fang Sun

Abstract read
PubMed Publisher
In one paragraph

Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaohui WangDepartment of Nephrology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, Shandong, China.
Jian TengDepartment of Nephrology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, Shandong, China.
Zhenzhen YuDepartment of Nephrology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, Shandong, China.
Ying SunDepartment of Nephrology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, Shandong, China.
Fang SunDepartment of Nephrology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, Shandong, China. bingdian0606x@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the role of S1PR3 in ectopic lipid deposition in diabetic nephropathy (DN) and its underlying mechanisms. The DN rat model was constructed and treated with adeno-associated virus (AAV9) cloned with S1PR3 overexpression or knockdown on the 7th and 49th day after STZ injection. Rat body weight, fasting plasma glucose (FPG), 24-hour urine output and urine protein, renal function, and blood lipids were all tested at different time points after AAV9 injection. 12 weeks post-AAV9 injection, pathological changes and ectopic lipid deposition in renal tissue were detected. In addition, to validate the role of AMPK/PPAR-γ/GPAT

Indexed as

AMPK/PPAR- γ/GPAT3 pathwayDiabetes nephropathyEctopic lipid depositionLipid synthesis and lipolysisS1PR3

Identifiers

PMID42268342

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.