ArticlePloS one2026
Plasma vitamin C levels are associated with brain structural networks on MRI: A large cohort study.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeurodegenerative diseases significantly impact brain health in older adults, and although dietary vitamin C intake has been associated with a reduced risk of cognitive impairment, it remains unclear whether plasma vitamin C levels independently affect brain structure and neural connectivity. This study aimed to investigate whether plasma vitamin C levels were independently associated with brain volume and default mode network (DMN) connectivity in older adults.
methodsAll participants underwent 3T magnetic resonance imaging (MRI). Total intracranial volume (ICV), gray matter volume (GMV), and white matter volume (WMV) were calculated using CAT 12 in SPM 12. DMN connectivity was assessed using independent component analysis, based on shared GMV variance across voxels, and quantified by the loading coefficients. Multiple regression analysis was used to investigate the associations among brain volume, DMN connectivity measurements, and plasma vitamin C levels. These analyses were adjusted for potential confounders (age, sex, Mini-Mental State Examination score, diabetes, hypertension, hyperlipidemia, and education levels), and lifestyle factors (smoking history, drinking history, and physical activity). GMV/ICV ratio and WMV/ICV ratio were calculated to adjust for individual differences in head size.
resultsThis cross-sectional study included 2,044 participants (median age, 69 years; females, 61.1%). Low plasma vitamin C levels were significantly and independently associated with the GMV/ICV ratio (p < 0.001) and DMN connectivity (p < 0.001).
conclusionsIn conclusion, our findings demonstrate that plasma vitamin C levels are positively associated with the structural integrity of the gray matter and DMN connectivity, generating the hypothesis that vitamin C may play a role in brain health.
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