In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
21 authors.
Tianze GuoAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-6280-5902 Ziyue ZhuAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Yunjia QuShu Chien-Gene Lay Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, CA, USA.
Xi YuAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0009-0004-5003-7298 Linshan ZhuAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-3849-3237 Yuxuan WangAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Kunshu LiuAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Jiaxin CuiAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-8318-0008 Xue DongAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0009-0003-1233-8674 Chi-Woo YoonAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-4619-7083 Cem Yigit KilicAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-3022-2718 Peixiang HeShu Chien-Gene Lay Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, CA, USA.ORCID 0009-0008-6933-2077 Shuangquan GouAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Yushun ZengAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-5995-4085 Priyankan DattaDepartment of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, CA, USA.
Qifa ZhouAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-1527-3020 Hongquan XuDepartment of Statistics and Data Science, University of California, Los Angeles, Los Angeles, CA, USA.
Ishwar K PuriAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-8713-4188 Longwei LiuAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-4229-9066 Keyue ShenAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-9605-1635 Yingxiao WangAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-0265-326X Funding
Acoustothermogenetics for Cell EngineeringR35GM140929 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WANG, YINGXIAO · 2021 to 2025
$2.9M(PQ5) Microenvironmental Regulation of Mitochondrial Heterogeneity in Cancer MetastasisR01CA220012 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHEN, KEYUE · 2019 to 2023
$2.2MNCI NIH HHS R01 CA220012NIGMS NIH HHS R35 GM140929
6 · The paper itselfAbstract
CAR-T therapy is highly effective in hematologic malignancies but remains challenging in solid tumors. To address this challenge, here, we developed SHIFTERS (solid-tumor hallmark inducible, focused-ultrasound triggered enhanced reprogramming system), an AND-gated circuit that rewires tumor hallmarks into the clinically validated antigen CD19 under focused-ultrasound (FUS) control. SHIFTERS uses a split Gal4-VP64 transcription factor with one module driven by a hypoxia-responsive promoter and the other by a FUS-inducible heat-shock promoter, restricting CD19 induction to sonicated, hallmark-positive regions. This design enables robust, sustained local CD19 expression to activate and train CD19 synNotch CAR-T cells. In 3D spheroids and in vivo models, hypoxia-gated SHIFTERS combined with synNotch CAR-T cells achieved strong tumor suppression, supporting FUS-guided, localized activation. SHIFTERS is modular and can be adapted to tumor-type-specific promoters such as enAFP in hepatocellular carcinoma to enable both spatial and cell type-specific targeting. Together, SHIFTERS provides a modular, tumor-constrained, ultrasound-controllable platform to improve the precision and efficacy of CAR-T therapy for solid tumors.
Indexed as
Immunotherapy, AdoptiveNeoplasmsReceptors, Chimeric AntigenAnimalsCell Line, TumorHumansMicePromoter Regions, GeneticXenograft Model Antitumor AssaysReceptors, Chimeric Antigen
Identifiers
PMID42268944
PMCPMC13251842
What Socratic holds
Textmetadata
LicenceCC BY
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