Evidence map›Paper›PMID 42268947›Full record

ArticleScience advances2026

Programmed oral delivery of peptide therapeutics for multiorgan targeting in metabolic disorders of hyperglycemia and hyperuricemia.

Junyu Liu, Xupu Xing, Chang Wen, Haihong Chen, Wei Li, Yuqing Huang, Yi Wang, Xin-Hui Xing, Can Yang Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Junyu LiuInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.ORCID 0009-0002-0723-0637
Xupu XingInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.ORCID 0009-0003-9753-7858
Chang WenInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.ORCID 0009-0000-6135-3756
Haihong ChenInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Wei LiInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Yuqing HuangInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.ORCID 0009-0002-7392-7109
Yi WangInstitute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.ORCID 0000-0003-4028-2471
Xin-Hui XingInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.ORCID 0000-0001-6419-4770
Can Yang ZhangInstitute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.ORCID 0000-0002-6975-5781

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic metabolic disorders such as diabetes and hyperuricemia demand multiorgan therapeutic intervention, yet single-target therapies often fail to restore homeostasis. Here, we present an orally administered, multistage-targeted nanoplatform (P1P2NPs) for the sequential delivery of therapeutic peptides to distinct organs. P1P2NPs is composed of a bioresponsive polymer poly(β-amino ester)-disulfide bond-poly(carboxybetaine) (PAE-SS-PCB), 1,2-distearoyl-

Indexed as

Drug Delivery SystemsHyperglycemiaHyperuricemiaMetabolic DiseasesPeptidesAdministration, OralAnimalsHumansMicePeptides

Identifiers

PMID42268947
PMCPMC13251837

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.