Evidence map›Paper›PMID 42269044›Full record

ArticleProceedings (Baylor University. Medical Center)2026

The burden and outcomes of vaccine-preventable infections among adult congenital heart disease patients: a nationwide analysis.

Izhan Hamza, Abdul Mukhtadir Kalaiger, Salman Khalid, Taha Mansoor, Mahmoud Ismayl, Rama Ellauzi, Amer Abdulla, Khaled Chatila, Abdullah Aftab, Mounisha Kethineni and 1 more

Abstract read
In one paragraph

Article in Proceedings (Baylor University. Medical Center), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Izhan HamzaDepartment of Cardiovascular Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Abdul Mukhtadir KalaigerDepartment of Internal Medicine, Montefiore Medical Center, Bronx, New York, USA.ORCID 0009-0005-2198-0014
Salman KhalidDepartment of Internal Medicine, CMH Lahore, Lahore, Pakistan.
Taha MansoorDepartment of Internal Medicine, Western Michigan University, Kalamazoo, Michigan, USA.
Mahmoud IsmaylDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Rama EllauziDepartment of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA.
Amer AbdullaDepartment of Cardiovascular Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Khaled ChatilaDepartment of Cardiovascular Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Abdullah AftabDepartment of Internal Medicine, NYU Grossman School of Medicine, New York, New York, USA.
Mounisha KethineniDepartment of Radiology, Sri Venkateshwara Med City, Chennai, India.
Andrew GoldsweigDepartment of Cardiovascular Medicine, Baystate Medical Center and University of Massachusetts-Baystate, Springfield, Massachusetts, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComorbidities increase the risk of adverse outcomes from infections. This study aimed to assess the prevalence and outcomes of vaccine-preventable infections (VPI) in adult congenital heart disease (ACHD) patients compared to the general population.

methodsUsing the 2016-2020 National Inpatient Sample database, we identified VPI hospitalizations and compared outcomes between ACHD patients and the general population. The primary study outcome was in-hospital mortality, with secondary outcomes including respiratory failure, acute kidney injury, acute liver failure, septic shock, cardiac arrest, length of stay, and total hospital charges.

resultsOf 647,440 patients hospitalized for VPI, 2610 (0.3%) had ACHD. After adjustment for baseline characteristics, ACHD patients had similar odds of in-hospital mortality (adjusted odds ratio [aOR] 1.12, 95% confidence interval [CI] 0.64-1.98), respiratory failure (aOR 1.05, 95% CI 0.84-1.32), septic shock (aOR 1.03, 95% CI 0.66-1.60), and cardiac arrest (aOR 1.01, 95% CI 0.36-2.74), but higher odds of acute kidney injury (aOR 1.34, 95% CI 1.09-1.67) and acute liver failure (aOR 1.27, CI 1.01-1.60) compared to the general population.

conclusionACHD patients hospitalized for VPI have similar in-hospital mortality, but higher acute kidney injury and liver failure rates compared to the general population, highlighting the importance of vaccination in this vulnerable patient group.

Indexed as

Heart Defects, CongenitalAcute Kidney InjuryAdultFemaleHospitalizationHospital MortalityHumansMaleMiddle AgedPrevalenceUnited StatesAdult congenital heart diseaseinfluenzapneumococcusvaccine

Identifiers

PMID42269044
PMCPMC13271347

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.