Evidence map›Paper›PMID 42269711›Full record

ArticleCell proliferation2026

Targeting PCSK9 in Vascular Smooth Muscle Cells: An Effective Strategy to Suppress Ferroptosis and Attenuate Abdominal Aortic Aneurysm Progression.

Mengdie Xia, Man Li, Yanyu Chen, Jialin Chen, Yuting Cui, Xi-Long Zheng, Jing Yang, Bingzhao Li, Xiaofeng Ma, Miao Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mengdie XiaDepartment of Cardiology, Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Man LiInstitute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hunan, China.
Yanyu ChenInstitute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hunan, China.
Jialin ChenInstitute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hunan, China.
Yuting CuiInstitute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hunan, China.
Xi-Long ZhengDepartments of Biochemistry & Molecular Biology and Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Jing YangDepartment of Metabolism and Endocrinology, Shenzhen University Sixth Affiliated Hospital, Shenzhen Nanshan People's Hospital, Guangdong, China.
Bingzhao LiDepartment of Cardiology, Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Xiaofeng MaDepartment of Cardiology, Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Miao LiuDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-3365-0213
Gang FanDepartment of Urology, Shenzhen University Sixth Affiliated Hospital, Shenzhen Nanshan People's Hospital, Guangdong, China.
Juan PengInstitute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hunan, China.
Xiaoyan DaiDepartment of Cardiovascular Medicine, the Second Affiliated Hospital, University of South China, Hunan, China.
Zhihan TangDepartment of Cardiology, Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.

Funding

National Natural Science Foundation of China 82570537National Natural Science Foundation of China 82571829Science and Technology Program of Hunan Province 2025JJ90126Science and Technology Program of Hunan Province 2025JJ90128Science and Technology Program of Hunan Province R2023046
6 · The paper itself

Abstract

Abdominal aortic aneurysm (AAA) lacks effective pharmacotherapy. This study examines whether proprotein convertase subtilisin/kexin type 9 (PCSK9) drives ferroptosis in vascular smooth muscle cells (VSMCs) and whether its pharmacological degradation mitigates disease progression. PCSK9 is enriched in VSMCs of human AAA and in murine models induced by PPE or Ang II. SMC-specific PCSK9 overexpression (PCSK9

Indexed as

abdominal aortic aneurysmferroptosisPCSK9PROTACvascular smooth muscle cells

Identifiers

PMID42269711
PMCPMC13326032

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.