Evidence map›Paper›PMID 42270629›Full record

ArticleNature communications2026

A generalist biomedical vision-language model via multi-CLIP knowledge distillation.

Shansong Wang, Zhecheng Jin, Mingzhe Hu, Mojtaba Safari, Yuan Gao, Feng Zhao, Chih-Wei Chang, Richard Lj Qiu, Justin Roper, David S Yu and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Prostate Cancer Classification Using Quantum Machine Learning on Multi-parametric MRI.Proceedings of SPIE--the International Society for Optical Engineering · 2026
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shansong WangDepartment of Radiation and Cellular Oncology, The University of Chicago, Chicago, USA.ORCID 0000-0003-4208-2035
Zhecheng JinDepartment of Biomedical Engineering, College of Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Mingzhe HuDepartment of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-7523-8927
Mojtaba SafariDepartment of Radiation and Cellular Oncology, The University of Chicago, Chicago, USA.ORCID 0000-0003-3295-328X
Yuan GaoDepartment of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.
Feng ZhaoSchool of Electrical and Computer Engineering, College of Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Chih-Wei ChangDepartment of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-3818-4381
Richard Lj QiuDepartment of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-7877-1900
Justin RoperDepartment of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.
David S YuDepartment of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.
James Edward BaciakDepartment of Materials Science and Engineering, University of Florida, Gainesville, FL, USA.
Xiaofeng YangDepartment of Radiation and Cellular Oncology, The University of Chicago, Chicago, USA. xfyang@uchicago.edu.

Funding

eXtended Modular ANthropomorphic (XMAN) phantom for Imaging and Treatment Optimization in Radiotherapy.R01EB032680 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE · PI REN, LEI, YANG, XIAOFENG · 2022 to 2025
$2.4M
Real-time Volumetric Imaging for Motion Management and Dose Delivery VerificationR01CA272991 · NCI · EMORY UNIVERSITY · PI Zhen Tian, Xiaofeng Yang · 2023 to 2026
$2.3M
Intelligent and Personalized Online Adaptive Proton TherapyR01DE033512 · NIDCR · UNIVERSITY OF CHICAGO · PI Zhen Tian, Xiaofeng Yang · 2024 to 2026
$1.8M
Artificial Intelligence Driven Platform for PET/MR ImagingR56EB033332 · NIBIB · EMORY UNIVERSITY · PI MAO, HUI, YANG, XIAOFENG · 2022 to 2022
$764k
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01CA272991Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01DE033512Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01EB032680Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R56EB033332NCI NIH HHS R01 CA272991NIBIB NIH HHS R01 EB032680NIBIB NIH HHS R56 EB033332NIDCR NIH HHS R01 DE033512
6 · The paper itself

Abstract

Contrastive Language-Image Pretraining (CLIP) models, which are pretrained on natural images with billions of image-text pairs, exhibit strong zero-shot and cross-modal capabilities. However, their application in biomedicine remains challenging due to limited large-scale image-text data and heterogeneous imaging modalities. Here we show that a generalist biomedical foundation model can be effectively built via multimodal medical knowledge distillation. We introduce MMKD-CLIP, which integrates complementary knowledge from nine biomedical CLIP models. Our two-stage pipeline combines CLIP-style pretraining on 2.9 million biomedical image-text pairs across 26 modalities with large-scale feature-level distillation. We evaluate MMKD-CLIP on 58 datasets spanning nine modalities and six tasks, including classification, retrieval, visual question answering, survival prediction, and cancer diagnosis. MMKD-CLIP performs favorably relative to the teacher models, with results supporting its robustness and cross-domain generalization.

Indexed as

LanguageNatural Language ProcessingHumansNeoplasms

Identifiers

PMID42270629
PMCPMC13402289

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.