Evidence map›Paper›PMID 42270683›Full record

ArticleScientific data2026

Computer-Interpretable Domain Knowledge for Drug-Induced Acute Kidney Injury: a Knowledge Graph Approach.

Romy Vos, Iacopo Vagliano, Cornelis Boersma, Frank van Harmelen, Annette Ten Teije, Joanna E Klopotowska, LEAPfROG Consortium

Abstract readDataset
In one paragraph

Article in Scientific data, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Romy VosDepartment of Computer Science, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. r.m.p.vos@student.vu.nl.
Iacopo VaglianoDepartment of Medical Informatics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Cornelis BoersmaDepartment of Strategic Management, Open Universiteit, Heerlen, the Netherlands.
Frank van HarmelenDepartment of Computer Science, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Annette Ten Teije *Department of Computer Science, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Joanna E Klopotowska *Department of Medical Informatics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
LEAPfROG Consortium

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek KICH1.ST01.20.011
6 · The paper itself

Abstract

In this study, a Knowledge Graph (KG) for Drug-Induced Acute Kidney Injury (DAKI) was developed to provide structured and standardized knowledge about drugs known to cause AKI. The DAKI-KG is integrated from several credible domain sources, which we standardized to international vocabularies. We demonstrate the applicability of the DAKI-KG through competency questions and expert evaluations. The envisioned two application areas are: (1) the KG can be used as input for a decision support tool to get insights into potential side-effects and drug-drug interactions harmful for kidneys, especially in patients with chronic kidney disease and (2) researchers can utilize the KG to derive confounders and variables for (causal) machine learning models or as input into link prediction methods. The evaluation results show the applicability of our KG through varying competency questions and use cases, though further improvements are needed before it is ready for clinical application. We anticipate the DAKI-KG to be relevant for tasks such as confounder identification, variable analysis, and the development of QA systems.

Indexed as

Acute Kidney InjuryDrug-Related Side Effects and Adverse ReactionsHumansMachine Learning

Identifiers

PMID42270683
PMCPMC13594175

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.