ArticleMolecular psychiatry2026
GluD1 is localized at cholinergic synapses and is an acetylcholine receptor.
Poojashree B Chettiar, Kishore Kumar S Narasimhan, Siddhesh S Sabnis, Spencer S Ericksen, Diane Choi, Yoland Smith, Shashank M Dravid
Abstract read
In one paragraphArticle in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Poojashree B Chettiar *Department of Psychiatry and Behavioral Sciences, Naresh K. Vashisht College of Medicine, Texas A&M University, 206, Olsen Blvd, Reynolds Medical Sciences Bldg., College Station, TX, 77845, USA.
Kishore Kumar S Narasimhan *Department of Psychiatry and Behavioral Sciences, Naresh K. Vashisht College of Medicine, Texas A&M University, 206, Olsen Blvd, Reynolds Medical Sciences Bldg., College Station, TX, 77845, USA.
Siddhesh S SabnisDepartment of Psychiatry and Behavioral Sciences, Naresh K. Vashisht College of Medicine, Texas A&M University, 206, Olsen Blvd, Reynolds Medical Sciences Bldg., College Station, TX, 77845, USA.
Spencer S EricksenDrug Development Core, Small Molecule Screening Facility, University of Wisconsin, Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0003-4907-1160 Diane ChoiEmory National Primate Research Center, Emory University, Atlanta, GA, USA.
Shashank M DravidDepartment of Psychiatry and Behavioral Sciences, Naresh K. Vashisht College of Medicine, Texas A&M University, 206, Olsen Blvd, Reynolds Medical Sciences Bldg., College Station, TX, 77845, USA. smdravid@tamu.edu.ORCID http://orcid.org/0000-0002-9912-8148 Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MUW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6MTrans-synaptic signaling complex in amygdala pain mechanismsR01NS118731 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI DRAVID, SHASHANK MANOHAR, NEUGEBAUER, VOLKER · 2020 to 2024
$2.7MFunction of glutamate delta-1 receptorR01MH116003 · NIMH · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI DRAVID, SHASHANK MANOHAR · 2018 to 2022
$1.9MStructure-Function and Signaling of Glutamate Delta 1 in Pain MechanismR21NS132590 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI DRAVID, SHASHANK MANOHAR · 2023 to 2023
$404kNCI NIH HHS P30 CA014520NIMH NIH HHS R01 MH116003NINDS NIH HHS R01 NS118731NINDS NIH HHS R21 NS132590U.S. Department of Health & Human Services | National Institutes of Health (NIH) MH116003U.S. Department of Health & Human Services | National Institutes of Health (NIH) NS118731U.S. Department of Health & Human Services | National Institutes of Health (NIH) NS132590U.S. Department of Health & Human Services | National Institutes of Health (NIH) NS133338U.S. Department of Health & Human Services | National Institutes of Health (NIH) P51OD011132
6 · The paper itselfAbstract
The GluD1 receptor has many unusual features including expression at both excitatory and inhibitory synapses and a ligand binding domain capable of binding both D-serine and GABA. We have previously demonstrated that striatal GluD1 is critical for the regulation of behavioral flexibility, a phenotype dependent on the cholinergic system. Here, we found that GluD1 is enriched postsynaptically at cholinergic synapses in the mouse and monkey dorsal striatum. Further, loss of GluD1 reduces the abundance of cholinergic terminals, excitatory responses at cholinergic synapses as well as muscarinic receptor-induced plasticity. In addition, optogenetic stimulation of cholinergic interneurons or puff-application of ACh, in the presence of cholinergic and AMPA/GABA
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