Evidence map›Paper›PMID 42270830›Full record

ArticleNPJ cardiovascular health2026

Left atrial stiffness, exercise intolerance and injury biomarkers predict adverse outcomes in patients with heart failure with preserved ejection fraction.

Navazh Jalaludeen, Faye Forsyth, Jamie O'Driscoll, Jamie Edwards, Holly Pavey, Annette Hubsch, Joanna Helmy, Carmel M McEniery, Ian B Wilkinson, M Justin Zaman and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ cardiovascular health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03617848 (Optimising Management of Patients With Heart Failure With Preserved Ejection Fraction in Primary Care), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03617848 completednot on this map

Optimising Management of Patients With Heart Failure With Preserved Ejection Fraction in Primary Care

TypeobservationalSponsorProfessor Christi DeatonRan2018 to 2021Enrolled153ConditionsHeart Failure With Preserved Ejection Fraction
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Navazh JalaludeenDivision of Experimental Medicine & Immunotherapeutics, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK. navazhjalaludeen@nhs.net.
Faye ForsythPrimary Care Unit, Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, East Forvie, Cambridge Biomedical Campus, Cambridge, UK.
Jamie O'DriscollDiabetes Research Centre, College of Life Sciences, University of Leicester, Leicester, UK.
Jamie EdwardsSt George's University Hospitals NHS Foundation Trust, London, UK.
Holly PaveyDivision of Experimental Medicine & Immunotherapeutics, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Annette HubschDivision of Experimental Medicine & Immunotherapeutics, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Joanna HelmyDivision of Experimental Medicine & Immunotherapeutics, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Carmel M McEnieryDivision of Experimental Medicine & Immunotherapeutics, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Ian B WilkinsonDivision of Experimental Medicine & Immunotherapeutics, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.
M Justin ZamanWest Suffolk Hospital NHS Foundation Trust, Bury St Edmunds, UK.
Christi DeatonPrimary Care Unit, Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, East Forvie, Cambridge Biomedical Campus, Cambridge, UK.
Joseph CheriyanDivision of Experimental Medicine & Immunotherapeutics, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a complex condition associated with high morbidity and mortality. This exploratory study aimed to assess the prognostic value of left atrial (LA) stiffness, exercise tolerance, and selected biomarkers in patients with HFpEF. We evaluated LA mechanics using 2D speckle tracking in 43 patients (mean age: 77.2 years) from the OPTIMISE HFpEF study (NCT03617848). Biomarkers such as N-terminal pro-brain-type natriuretic peptide, growth differentiation factor 15, and galectin-3 were measured. Patients also completed a six-minute walk test. Over a mean follow-up of 24.5 months, there were five deaths (11.4%) and 21 all-cause hospitalisations (48.8%). LA stiffness (HR: 1.81; p = 0.028) and N-terminal pro-brain-type natriuretic peptide (HR: 1.01; p = 0.013) were independent mortality predictors. For hospitalisations, six-minute walk distance (HR: 0.99; p = 0.011) and growth differentiation factor 15 (HR: 1.01; p = 0.007) were significant independent predictors. This exploratory analysis indicates that LA stiffness, N-terminal pro-brain-type natriuretic peptide, exercise intolerance, and growth differentiation factor 15 independently predict adverse events in HFpEF. Implementing a comprehensive therapeutic approach, including lifestyle modifications, medical therapy, and, if necessary, more advanced interventions to improve LA mechanics, functional capacity, and clinical biomarkers, may improve outcomes for HFpEF patients.

Identifiers

PMID42270830
PMCPMC13328377

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.