Evidence map›Paper›PMID 42270939›Full record

ArticleAAPS PharmSciTech2026

Development of Resveratrol/Curcumin Dual-Loaded Chitosan/Sericin Hydrogel Films for Wound Healing: A Comparison Of Shrimp- and Crab-Sourced Chitosan.

Bui Thi Phuong Thuy, Phuong T M Ha, Nguyen Thi Ngoc Quyen, Nguyen Thi Kim Ngan, Ngoc Yen Nguyen, Nguyen Trong Tuan, Huynh Vu Thanh Luong, Tran Thi Bich Quyen, Trieu Phu Hau, Duy Toan Pham

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in AAPS PharmSciTech, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bui Thi Phuong ThuyFaculty of Basic Sciences, Van Lang University, Ho Chi Minh City, Vietnam.ORCID http://orcid.org/0000-0001-5487-414X
Phuong T M HaFaculty of Pharmacy and Nursing, Tay Do University, 68 Tran Chien Street, Thanh My Area, Cai Rang Ward, Can Tho City, Vietnam.ORCID http://orcid.org/0009-0007-4452-6281
Nguyen Thi Ngoc QuyenFaculty of Health Sciences, College of Natural Sciences, Can Tho University, Can Tho, Vietnam.ORCID http://orcid.org/0009-0002-2410-6558
Nguyen Thi Kim NganFaculty of Health Sciences, College of Natural Sciences, Can Tho University, Can Tho, Vietnam.ORCID http://orcid.org/0009-0007-5276-1820
Ngoc Yen NguyenFaculty of Health Sciences, College of Natural Sciences, Can Tho University, Can Tho, Vietnam.ORCID http://orcid.org/0009-0003-3630-2377
Nguyen Trong TuanFaculty of Health Sciences, College of Natural Sciences, Can Tho University, Can Tho, Vietnam.ORCID http://orcid.org/0000-0003-2132-113X
Huynh Vu Thanh LuongFaculty of Chemical Engineering, College of Engineering, Can Tho University, Can Tho, Vietnam.ORCID http://orcid.org/0000-0002-0647-3867
Tran Thi Bich QuyenFaculty of Chemical Engineering, College of Engineering, Can Tho University, Can Tho, Vietnam.ORCID http://orcid.org/0000-0002-9304-5544
Trieu Phu HauFaculty of Health Sciences, College of Natural Sciences, Can Tho University, Can Tho, Vietnam.ORCID http://orcid.org/0009-0005-8763-4317
Duy Toan PhamFaculty of Health Sciences, College of Natural Sciences, Can Tho University, Can Tho, Vietnam. pdtoan@ctu.edu.vn.ORCID http://orcid.org/0000-0002-8693-3367

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study reports the formulation and comparative evaluation of resveratrol and curcumin dual-loaded chitosan-based wound-healing films prepared from shrimp-derived chitosan (Shrimp-CTS, ~ 80 kDa, degree of deacetylation of ~ 95%) and crab-derived chitosan (Crab-CTS, ~ 100 kDa, degree of deacetylation of ~ 85%). The film was prepared by crosslinking reaction of chitosan and glutaraldehyde, and the influence of chitosan origin on film structure, swelling, drug release, skin permeability, and in vivo wound healing was investigated. Morphological analyses revealed that shrimp-CTS-films possessed heterogeneous surfaces, whereas crab-CTS-films exhibited smoother surfaces. Swelling studies showed that shrimp-CTS-films displayed a burst swelling, reaching 75-85% swelling within 30-60 min, while the crab-CTS-films exhibited sustained swelling, progressively increasing to ~ 100% after 240 min. All drug release profiles followed biphasic kinetics (a burst release phase and a sustained phase) and fitted well to the Korsmeyer-Peppas model (R

Indexed as

ChitosanCurcuminHydrogelsResveratrolWound HealingAnimalsBrachyuraDrug LiberationPenaeidaePermeabilitySkinSwineChitosanCurcuminHydrogelsResveratrolchitosancrabfilmsericinshrimpwound healing

Identifiers

PMID42270939

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.