Evidence map›Paper›PMID 42271055›Full record

ArticleNature2026

SIRT7 regulates dosage compensation and safeguards the female X chromosome.

Nicolas G Simonet, Joshua K Thackray, Barry Kesner, Anna Guitart-Solanes, François Serra, Maria Espinosa-Alcantud, Anna Lappala, Laia Marín-Gual, Cristina Marín-García, Uri Weissbein and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Nicolas G SimonetDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Joshua K ThackrayHuman Genetics Institute of New Jersey (HGINJ), Department of Genetics, Rutgers University, Piscataway, NJ, USA.
Barry KesnerDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Anna Guitart-SolanesChromatin Biology Laboratory, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.
François Serra3D Chromatin Organization Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.ORCID http://orcid.org/0000-0003-3895-4742
Maria Espinosa-AlcantudChromatin Biology Laboratory, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.
Anna LappalaDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Laia Marín-GualUnitat de Citologia i d'Histologia, Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.ORCID http://orcid.org/0000-0003-1480-0976
Cristina Marín-GarcíaUnitat de Citologia i d'Histologia, Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.
Uri WeissbeinDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Josema Castelló-GarcíaDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Moritz BauerCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Danni WangDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Llorenç Rovirosa3D Chromatin Organization Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.
Jay TischfieldHuman Genetics Institute of New Jersey (HGINJ), Department of Genetics, Rutgers University, Piscataway, NJ, USA.
Lourdes SerranoHuman Genetics Institute of New Jersey (HGINJ), Department of Genetics, Rutgers University, Piscataway, NJ, USA.
Bernhard PayerCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Aurora Ruiz-HerreraUnitat de Citologia i d'Histologia, Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.ORCID http://orcid.org/0000-0003-3868-6151
Berta N VazquezChromatin Biology Laboratory, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.
Biola M Javierre3D Chromatin Organization Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.
Alejandro VaqueroChromatin Biology Laboratory, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain. avaquero@carrerasresearch.org.ORCID http://orcid.org/0000-0002-8735-4156
Jeannie T LeeDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA. lee@molbio.mgh.harvard.edu.ORCID http://orcid.org/0000-0001-7786-8850

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sirtuins are deacetylases implicated in stress responses and longevity in mammals

Indexed as

Dosage Compensation, GeneticSirtuinsX ChromosomeAcetylationAnimalsDNA DamageFemaleGene SilencingGenes, X-LinkedHistonesLongevityMaleMiceRNA, Long NoncodingSex CharacteristicsX Chromosome InactivationHistonesRNA, Long NoncodingSirtuinsXIST non-coding RNA

Identifiers

PMID42271055

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.