Evidence map›Paper›PMID 42271116›Full record

SynthesisSports medicine (Auckland, N.Z.)2026

The Effect of Diet and Dietary Supplements on Iron Status of Active Females: A Systematic Review and Meta-analysis of Interventional Trials.

Emma McCarthy, Josh P Pekler, Tina Tran, Lauren E Deluca, Trina Fresco, Jarrad Hampton-Marcell, Beatriz Penalver Bernabe, Karrie Hamstra-Wright, Mary Dawn Koenig, Danielle Colegrove and 1 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Sports medicine (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emma McCarthyDepartment of Kinesiology and Nutrition, University of Illinois Chicago, 1919 West Taylor Street, Chicago, IL, 60612, USA. emccar6@uic.edu.ORCID http://orcid.org/0009-0002-7129-9911
Josh P PeklerDepartment of Kinesiology and Nutrition, University of Illinois Chicago, 1919 West Taylor Street, Chicago, IL, 60612, USA.
Tina TranCollege of Osteopathic Medicine, Kansas City University, Joplin, MO, 64804, USA.
Lauren E DelucaDepartment of Kinesiology and Nutrition, University of Illinois Chicago, 1919 West Taylor Street, Chicago, IL, 60612, USA.
Trina FrescoDepartment of Kinesiology and Nutrition, University of Illinois Chicago, 1919 West Taylor Street, Chicago, IL, 60612, USA.
Jarrad Hampton-MarcellDepartment of Biological Sciences, University of Illinois Chicago, Chicago, IL, 60612, USA.
Beatriz Penalver BernabeDepartment of Biomedical Engineering, University of Illinois Chicago, Chicago, IL, 60612, USA.
Karrie Hamstra-WrightDepartment of Kinesiology and Nutrition, University of Illinois Chicago, 1919 West Taylor Street, Chicago, IL, 60612, USA.
Mary Dawn KoenigDepartment of Human Development Nursing Science, University of Illinois Chicago, Chicago, IL, 60612, USA.
Danielle ColegroveDepartment of Athletic Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA.
Lisa Tussing-HumphreysDepartment of Kinesiology and Nutrition, University of Illinois Chicago, 1919 West Taylor Street, Chicago, IL, 60612, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIron deficiency is reported in about 15-35% of all female athletes. In addition to oral iron supplements, food-based approaches and dietary supplements have gained interest in preventing and treating iron deficiency in the active female population.

objectivesThis systematic review and meta-analysis aimed to evaluate the effect of diet and dietary supplement interventions on iron status, performance, and inflammatory markers in active females of reproductive age. DATA SOURCE: The search was conducted using PubMed, Scopus, CINAHL, Embase, and Rehabilitation & Sports Medicine Source up to March 2026. DATA EXTRACTION: Interventional trials that examined the impact of diet or dietary supplements on at least one biomarker of iron status in active females of reproductive age were included. DATA ANALYSIS: All meta-analyses were conducted in R version 2025.05.0 + 496 using the metafor package. Separate random-effects meta-analyses were performed for hemoglobin and ferritin outcomes.

resultsOral iron supplementation in the form of ferrous sulfate resulted in a significant increase in hemoglobin (mean difference [MD] = 0.42 g/dL; 95% confidence interval [CI]: 0.10 to 0.74; p = 0.0109; I

conclusionMeta-analysis revealed that ferrous sulfate supplementation significantly improved hemoglobin and ferritin levels in active females. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42024554679.

Indexed as

DietDietary SupplementsIronAnemia, Iron-DeficiencyBiomarkersFemaleFerritinsFerrous CompoundsHemoglobinsHumansBiomarkersFerritinsFerrous Compoundsferrous sulfateHemoglobinsIron

Identifiers

PMID42271116
PMCPMC13614990

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.