Evidence map›Paper›PMID 42271397›Full record

SynthesisBMC health services research2026

Youth-friendly health services for tuberculosis care: an integrative review and implementation science synthesis.

Adam Leonard, Elizabeth Di Giacomo, Jason E Farley, Nicole Salazar-Austin, Leslie A Enane

Abstract readReviewSystematic Review
In one paragraph

Synthesis in BMC health services research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adam LeonardCenter for Infectious Disease and Nursing Innovation (CIDNI), Johns Hopkins School of Nursing, 525 N Wolfe St, Baltimore, MD, 21205, USA. adam.leonard@ucsf.edu.ORCID http://orcid.org/0000-0003-1121-6993
Elizabeth Di GiacomoCenter for Infectious Disease and Nursing Innovation (CIDNI), Johns Hopkins School of Nursing, 525 N Wolfe St, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0009-0000-2367-5797
Jason E FarleyCenter for Infectious Disease and Nursing Innovation (CIDNI), Johns Hopkins School of Nursing, 525 N Wolfe St, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0002-6896-0134
Nicole Salazar-AustinDepartment of Pediatrics, Johns Hopkins School of Medicine, 733 N Broadway, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0002-9875-9319
Leslie A EnaneThe Ryan White Center for Pediatric Infectious Disease and Global Health, Department of Pediatrics, Indiana University School of Medicine, 705 Riley Hospital Drive, Indianapolis, IN, 46202, USA.ORCID http://orcid.org/0000-0001-8390-5881

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdolescents and young adults (AYAs) face disproportionate risk of tuberculosis (TB) due to biological vulnerability, mobility, distinct risks for HIV infection and treatment failure, structural barriers, and limited access to adolescent-responsive care. Although the World Health Organization recommends youth-friendly health services (YFHS), implementation in TB care has received little attention. This review synthesizes current evidence on the application of YFHS principles across the TB care continuum to inform models responsive to the needs of AYAs.

methodsAn integrative review was conducted using established methodology and included qualitative, quantitative, and conceptual studies of YFHS in TB care for individuals aged 10 to 24 years in high- and medium-burden countries. Searches were performed in four scientific databases. Two reviewers independently screened records, extracted data, and conducted quality appraisal using Joanna Briggs Institute tools. A deductive thematic synthesis was applied based on the five YFHS domains: for accessible, acceptable, equitable, appropriate, and effective care. Implementation gaps were examined using the integrated Promoting Action on Research Implementation in Health Services (i-PARIHS) framework.

resultsOf 6,067 records screened, 16 studies met inclusion criteria. Most focused on TB treatment, with limited attention to prevention or diagnosis. Strategies to improve accessibility included decentralized services, mobile health tools, and community-based models. Acceptability was related to respectful provider communication, youth-oriented spaces, and privacy protections to reduce stigma. Gaps in equitable care included restrictive consent laws and the absence of tailored services for vulnerable youth. Appropriateness emphasized the importance of integrated care and confidentiality, while effectiveness depended on staff training, clinical readiness, and prompt treatment initiation. Persistent implementation barriers included misaligned policies, fragmented service structures, and limited involvement of youth in service design.

conclusionsThere is an urgent need for adolescent-responsive TB strategies that align service delivery with the preferences and realities of AYAs. Standardized YFHS indicators, meaningful youth engagement, and context-sensitive facilitation approaches are critical to guide implementation. Integrating YFHS principles into national TB programs-supported by dedicated facilitators, cross-sectoral collaboration, and strengthened health systems-has the potential to improve care engagement and outcomes for AYAs living with or at risk of TB.

Indexed as

Adolescent Health ServicesHealth Services AccessibilityTuberculosisAdolescentChildHumansImplementation ScienceYoung AdultAdolescent health servicesCare engagementHealth service deliveryImplementation scienceTuberculosis

Identifiers

PMID42271397
PMCPMC13479411

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.