Evidence map›Paper›PMID 42271423›Full record

ArticleJournal of nanobiotechnology2026

Targeted

Keith Tang, Andrew Davis, Boyu Meng, Stephen R Adams, Judith Varner, Karen Messer, Eric T Ahrens

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Keith TangDepartment of Radiology, University of California San Diego, La Jolla, CA, USA.
Andrew DavisDepartment of Radiology, University of California San Diego, La Jolla, CA, USA.
Boyu MengDepartment of Radiation Medicine & Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Stephen R AdamsDepartment of Pharmacology, University of California San Diego, La Jolla, CA, USA.
Judith VarnerDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Karen MesserDepartment of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA.
Eric T AhrensDepartment of Radiology, University of California San Diego, La Jolla, CA, USA. eta@ucsd.edu.

Funding

Role of PI3Kinase in Tumor Progression and MetastasisR01CA167426 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Judith A VARNER · 2012 to 2026
$5.8M
Targeting the innate immune response in HNSCCR01DE027325 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Judith A VARNER · 2017 to 2026
$4.8M
Therapeutic Targeting of Macrophage PI3Kgamma in HNSCCR01CA226909 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kathryn Ann Gold, Judith A VARNER · 2018 to 2026
$3.9M
The lymph node microenvionment in tumor metastasisR01CA126820 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VARNER, JUDITH A · 2008 to 2012
$2.0M
Imaging tumor-associated macrophages in head and neck squamous cell carcinoma using fluorine-19 MRIR01CA290014 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ERIC T. AHRENS, Joseph A Califano · 2024 to 2026
$2.0M
CCR NIH HHS R01-CA290014NCI NIH HHS R01 CA126820NCI NIH HHS R01 CA167426NCI NIH HHS R01 CA226909NCI NIH HHS R01 CA290014NIDCR NIH HHS R01 DE027325
6 · The paper itself

Abstract

backgroundElevated levels of carcinoembryonic antigen (CEA) are strongly associated with several malignancies, including colorectal and hepatic adenocarcinomas, making CEA a clinically valuable biomarker. Targeted molecular imaging using positron emission tomography (PET) in combination with CEA-specific tracers offers the potential for improved tumor detection and longitudinal disease monitoring.

methodsWe developed a nanoemulsion (NE) platform incorporating a fluorous-encapsulated radiometal (FERM) chelate, in which

resultsIn vitro studies demonstrated specific binding of the targeted NEs in both protein- and cell-based assays using LS174T cells. In vivo PET/CT imaging of LS174T xenografts in nude mice revealed selective accumulation of the antibody-functionalized

conclusionClick-ready FERM NEs form a stable colloidal suspension of nanoscale droplets with a high radiometal payload and PET sensitivity. This targeted imaging platform shows strong potential for early detection and monitoring of cancer-associated biomarkers such as CEA. The modular design enables facile adaptation to a wide range of targeting ligands, supporting applications in molecular imaging and therapeutic delivery.

Indexed as

Carcinoembryonic AntigenPositron-Emission TomographyRadioisotopesZirconiumAnimalsCell Line, TumorEmulsionsHumansMiceMice, NudePositron Emission Tomography Computed TomographyRadiopharmaceuticalsTissue DistributionCarcinoembryonic AntigenEmulsionsRadioisotopesRadiopharmaceuticalsZirconiumZirconium-89CancerCarcinoembryonic antigenNanoemulsionPerfluorocarbonPETZirconium-89

Identifiers

PMID42271423
PMCPMC13479599

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.