ReviewFrontiers in cell and developmental biology2026
Stem cell dysfunction and rejuvenation strategies in ageing: emerging advances in regenerative medicine.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Ageing is a complicated phenomenon that is defined by the progressive decline in the body's functions that leads to weakened regenerative potential and greater vulnerability to various age-related diseases. There is evidence that highlights that stem cell dysfunction and exhaustion are the primary reasons for tissue degeneration that progresses with age and hence provide aid to regenerative therapeutic approaches. Stem cells have shown the ability to influence age-related cellular dysfunction in preclinical models mainly via paracrine signaling, immune modulation and tissue repair processes. Nonetheless, clinical evidence primarily confines to early-phase trials, showing inconsistent results based on cell type, delivery method and disease context. Several types of stem cells are being studied rigorously for their regenerative, immunomodulatory, and anti-ageing properties. Pre-clinical and early-phase clinical studies suggest potential benefits of stem cell-based interventions in musculoskeletal, cardiovascular and neurodegenerative disorders although effect sizes vary and long-term efficacy remains under investigation. Furthermore, emerging technologies such as tissue reprogramming, senolytics and niche modulation also contribute to improving therapeutic strategies. This review aims to provide a comprehensive overview of the existing knowledge of stem cell biology and therapies from various preclinical and clinical studies, along with rejuvenation approaches.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.