ArticleFrontiers in pharmacology2026
The synergistic protective effects of bioactive catechins in longjing tea: alleviate indomethacin-induced gastric toxicity through modulation of inflammatory and apoptotic pathways.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Methods: The composition of LT was determined using HPLC (High-Performance Liquid Chromatography). The control group received only tap water via the oral route for 14 days. The indomethacin-only group was administered 100 mg/kg indomethacin in a single oral dose following 24-h fasting. The indomethacin + famotidine group received 40 mg/kg famotidine via the oral route 1 hour before gastric ulcer induction. The members of the indomethacin + LT group received oral LT for 14 consecutive days. A gastric ulcer was induced after 24-h of fasting, and the experimental groups were sacrificed at the end of the sixth hour. Malondialdehyde, glutathione, cyclooxygenase 1 and 2, vascular endothelial cell growth factor A, nuclear factor kappa B, cleaved Poly ADP-ribose polymerase, pan-Akt, and p-Akt levels were examined at the tissue level. Results: Oxidative stress and inflammation, increased by indomethacin, activated the apoptotic cascade. LT showed partial anti-oxidative changes but significantly suppressed PARP-1 expression. The limited bioavailability of catechins may have restricted protective efficacy. Conclusion: The research showed that LT may be a promising agent with partial antioxidant, anti-inflammatory, and anti-apoptotic properties.
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