ArticleBrain communications2026
Lateralized excitation-inhibition rebalance correlates with motor recovery following hemispheric surgery.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hemispheric epilepsy surgery effectively achieves seizure control, yet post-operative motor recovery remains challenging. Whether motor compensation is linked to the excitation-inhibition balance in the unaffected hemisphere (UH) remains unclear. Using scalp EEG, we quantified the aperiodic exponent of the power spectrum as a non-invasive biomarker of cortical excitation-inhibition ratio (where a flatter spectral slope reflects neural excitation). We retrospectively analysed 46 patients who underwent hemispheric surgery and 23 age-matched unilateral non-hemispheric controls. Motor function was measured preoperatively and 3 months post-operatively, with preoperative status classified as preserved or impaired. We assessed preoperative inter-hemispheric asymmetry, post-operative UH modulation and their linear interaction in predicting motor improvement. Jackknife mapping was used to identify the contribution of a specific scalp sensor. Our results show that the hemispheric cohort exhibited a distinct preoperative excitation-inhibition asymmetry (
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