ArticleWorld journal of critical care medicine2026
Association of early interleukin-6 level with injury severity and mortality in trauma patients: Systematic review and meta-analysis.
Article in World journal of critical care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPolytrauma is associated with the release of various biomarkers, including interleukin (IL)-6, a proinflammatory cytokine with prognostic value.
aimTo evaluate the association between IL-6 measured within the first 24 hours of admission and the injury severity score (ISS) among adult polytrauma patients and to explore the link between early IL-6 levels and in-hospital mortality.
methodsWe conducted a systematic review and meta-analysis of articles published between 2004 and 2024 in the OVID EMBASE and PubMed databases. The primary outcomes of interest were ISS and all-cause in-hospital mortality. Heterogeneity among the included studies was assessed using the
resultsA total of 1126 studies were screened, of which 15 were selected, yielding 2106 polytrauma patients. The pooled effect size for the correlation between IL-6 and ISS using the Pearson's coefficient was 0.49 [95%CI: 0.36-0.60;
conclusionAmong polytrauma patients, elevated IL-6 levels within the first 24 hours of admission are associated with higher rates of severe injury and in-hospital mortality. Future research should investigate how early IL-6 levels can be used with other biomarkers to predict injury severity and worse outcomes. Additionally, larger-scale studies should be conducted to assess the tool's validity across a variety of populations.
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