ReviewSmart medicine2026
Freeze-Derived Microporous Biomaterials for Tissue Engineering Applications.
Review in Smart medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue engineering holds immense promise to revolutionize regenerative medicine by enabling the fabrication of functional, patient-specific tissues and organs for clinical translation, yet it continues to face persistent challenges in designing scaffolds that simultaneously recapitulate native tissue architecture, support cell viability, and enable efficient mass transport. Traditional fabrication has moved the field forward, yet routinely falls short of producing hierarchical, anisotropic, biomimetic structures under gentle conditions. Ice-templating (or freeze-casting), which is based on freeze-induced microphase separation, reframes the problem as crystal-growth engineering. This review summarizes current fabrication strategies and their underlying mechanism of ice-templating technology from physical and chemical perspectives. We then highlight recent advances in ice-templating for tissue engineering application fields such as 3D cell culture, wound healing, bone regeneration, nerve repair, and liver support, emphasizing the relationship between microstructure and biomedical functional performance. Finally, we discuss the key challenges in translating ice-templated biomaterials from laboratory research to clinical practice and outline future directions to fully harness this versatile biomedical strategy.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.