ArticleWorld journal of gastrointestinal pharmacology and therapeutics2026
Frequency and predictors of small intestinal bacterial overgrowth in acute pancreatitis.
Article in World journal of gastrointestinal pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAcute pancreatitis (AP) is associated with intestinal dysmotility, barrier dysfunction, and dysbiosis, which may increase the risk of small intestinal bacterial overgrowth (SIBO). Evidence on the prevalence of SIBO in AP and its clinical correlates is limited.
aimTo evaluate the frequency of SIBO in patients with AP and identify the clinical, laboratory, and imaging predictors of SIBO.
methodsThis hospital-based case-control study was conducted at a tertiary gastroenterology unit in New Delhi, India, from December 2022 to June 2024. Consecutive adults with AP were enrolled as cases, and age- and sex-matched healthy controls (HCs) were included. The glucose hydrogen breath test was used for the diagnosis of SIBO. The predictors of SIBO were examined.
resultsIn total, 30 cases and 60 HC were included in the study. SIBO was detected in 12 (40.0%) cases, significantly higher than in HC (1.7%) (
conclusionSIBO was frequent in AP and was strongly associated with disease severity. Larger prospective studies are required to determine whether identifying and treating SIBO can improve clinical outcomes in AP.
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