ArticleWorld journal of gastrointestinal pharmacology and therapeutics2026
Surgical interventions in inflammatory bowel disease: Indications, techniques, outcomes, and future directions.
Article in World journal of gastrointestinal pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundInflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is a chronic relapsing condition in which surgical intervention remains a cornerstone of management despite advances in medical therapy. Surgery plays a definitive role in UC and a complication-directed, bowel-preserving role in CD.
aimTo provide a comprehensive narrative overview of contemporary surgical management in IBD, focusing on indications, operative strategies, perioperative optimization, postoperative outcomes, and future directions.
methodsA narrative review was conducted following the principles of the PRISMA 2009 guidelines. A comprehensive literature search of PubMed/MEDLINE, EMBASE, Scopus, and the Cochrane Library was performed for studies published between January 2000 and December 2024. Relevant original studies, systematic reviews, and meta-analyses addressing surgical interventions in adult IBD patients were included. Evidence was synthesized descriptively.
resultsSurgical indications in UC include medically refractory disease, dysplasia or malignancy, and life-threatening complications, with restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA) representing the standard elective procedure. In CD, surgery is primarily indicated for fibrostenotic and penetrating complications, with emphasis on bowel-sparing approaches such as limited resection and strictureplasty. Minimally invasive and robotic techniques have demonstrated favorable short-term outcomes without compromising long-term results. Perioperative optimization-including nutritional support, steroid minimization, and appropriate integration of biologic therapy-plays a critical role in reducing complications. Postoperative recurrence in CD and pouch-related disorders following IPAA remain major challenges, requiring structured surveillance and multidisciplinary care.
conclusionSurgery continues to play a vital and evolving role in the management of IBD. Advances in surgical techniques, perioperative care, and integration with medical therapy have improved outcomes and quality of life. Optimal results depend on individualized decision-making within a multidisciplinary framework, with ongoing research needed to refine strategies for recurrence prevention and long-term functional preservation.
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