ArticleFrontiers in clinical diabetes and healthcare2026
Incidence and factors associated with hypoglycemia in newly diagnosed hospitalized children and adolescents with type 1 diabetes mellitus in China.
Article in Frontiers in clinical diabetes and healthcare, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the incidence and associated factors of hypoglycemia in hospitalized children and adolescents with newly diagnosed type 1 diabetes mellitus(T1DM) at a pediatric medical center in China. Research design and methods: This retrospective study included 567 children and adolescents aged <18 years with newly diagnosed T1DM hospitalized between January 1, 2016, and January 1, 2023. Hypoglycemia was defined as blood glucose <3.9 mmol/L (grade 1: 3.0-3.9 mmol/L; grade 2: <3.0 mmol/L).Between-group comparisons were performed using independent samples t-test, χ2-test, Mann-Whitney U-test, and binary logistic regression analysis to identify factors associated with hypoglycemia. Results: Among 567 patients, The total number of blood glucose measurements during hospitalization was 50,626.Hypoglycemia (<3.9 mmol/L) occurred 2,545 times, with an incidence density of 5.03%.Regarding severity 1,995 episodes of grade 1 hypoglycemia occurred(incidence density 3.94%), and 550 episodes of grade 2 hypoglycemia occurred(incidence density 1.08%).In terms of frequency, 81.66% (463/567) of patients had at least 1 hypoglycemia episode during hospitalization. Among those, 15.87% (90/567) had one episode, 12.52% (71/567) had two episodes, and 53.26% (302/567) had three or more episodes. The recurrence rate (≥2 episodes) was 65.78%(373/567 ).Regarding timing, grade 1 hypoglycemia occurred most frequently at night (00:00-06:00), while the highest event density for grade 2 was observed in the pre-lunch period (09:00-12:00). Multifactorial logistic regression analysis showed that age 7-12 years(OR = 0.421,95%CI=0.244-0.727,p Conclusions: Hypoglycemia is common among newly diagnosed hospitalized children and adolescents with T1DM in China, particularly at night for grade 1 events. Age, hospitalization days, insulin regimen, fasting C-peptide, and fasting insulin were associated with hypoglycemia. These associations, particularly for insulin regimen, should be interpreted considering potential confounding by indication due to the observational study design. These findings may inform targeted prevention strategies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.