ArticleFrontiers in immunology2026
Single cell transcriptome signatures and cell-cell interactions associated with sarcoidosis in lung immune cell populations.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sarcoidosis is a complex, multi-system granulomatous disease characterized by immune dysregulation and chronic inflammation, primarily affecting the lungs. To identify cell specific molecular changes associated with sarcoidosis development and progression, we aimed to characterize cellular composition, gene expression patterns, and cell-cell interactions in bronchoalveolar lavage (BAL) cells from patients with pulmonary sarcoidosis and healthy controls. Methods: Single cell RNA-seq on 16 sarcoidosis cases (8 progressive and 8 non-progressive) and 14 controls were analyzed to identify differences in cell proportions by disease group using F-tests and differential gene expression (DE) using pseudobulk analysis. Enriched pathways and upstream regulators were identified using Ingenuity Pathway Analysis (IPA). Cell-to-cell communication and ligand-receptor interaction analyses were performed using CellChat. Results: We identified significant DE of genes and pathways associated with sarcoidosis in resident macrophages (upregulation of Conclusions: These findings underscore the complexity of immune cell involvement in pulmonary sarcoidosis and highlight potential cellular and molecular targets for further investigation.
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