Evidence map›Paper›PMID 42273706›Full record

ArticleFrontiers in immunology2026

Pharmacological and genetic modulation of IL-32 expression in intestinal epithelial cells does not impact HIV-1 outgrowth in co-cultured CD4

Etiene Moreira Gabriel, Julie Moreaux, Chernkhwan Kaofai, Kimiya Majidi Ivari, Jean-François Schmouth, Jean-Philippe Goulet, Jonathan Dias, Tomas Raul Wiche Salinas, Laurence Raymond Marchand, Soumia Khalfi and 5 more

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Etiene Moreira GabrielCentre hospitalier de l'Université de Montréal (CHUM) Research Centre, Montréal, QC, Canada.
Julie MoreauxDepartment de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université de Montréal, Montréal, QC, Canada.
Chernkhwan KaofaiDepartment de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université de Montréal, Montréal, QC, Canada.
Kimiya Majidi IvariCentre hospitalier de l'Université de Montréal (CHUM) Research Centre, Montréal, QC, Canada.
Jean-François SchmouthCentre hospitalier de l'Université de Montréal (CHUM) Research Centre, Montréal, QC, Canada.
Jean-Philippe GouletCellCarta, Montréal, QC, Canada.
Jonathan DiasCentre hospitalier de l'Université de Montréal (CHUM) Research Centre, Montréal, QC, Canada.
Tomas Raul Wiche SalinasCentre hospitalier de l'Université de Montréal (CHUM) Research Centre, Montréal, QC, Canada.
Laurence Raymond MarchandCentre hospitalier de l'Université de Montréal (CHUM) Research Centre, Montréal, QC, Canada.
Soumia KhalfiCentre hospitalier de l'Université de Montréal (CHUM) Research Centre, Montréal, QC, Canada.
Jean-Pierre RoutyMcGill University Health Centre, Montreal, QC, Canada.
Madeleine DurandCentre hospitalier de l'Université de Montréal (CHUM) Research Centre, Montréal, QC, Canada.
Mohamed El-FarDepartment de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université de Montréal, Montréal, QC, Canada.
Cécile L TremblayCentre hospitalier de l'Université de Montréal (CHUM) Research Centre, Montréal, QC, Canada.
Petronela AncutaCentre hospitalier de l'Université de Montréal (CHUM) Research Centre, Montréal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The crosstalk between intestinal epithelial cells (IEC) and CD4 Methods: HT-29 IEC were activated with TNF and/or IL-22, IL-26, Results: In combination with TNF, IL-22 upregulated IL-32β/ϵ, RGZ increased IL-32β, ATRA decreased IL-32β/γ/ϵ, while IL-26 had no impact in IEC. HIV-1 outgrowth in IEC:T-cell co-cultures was not affected by IL-22/RGZ/ATRA-mediated changes in IL-32 expression. The analysis of differentially expressed genes in control Conclusions: We identified IL-22, ATRA and RGZ as novel regulators of IL-32 expression in TNF-primed IEC and demonstrated that pharmacological and genetic modulation of IL-32 expression in IEC has no major impact on HIV-1 outgrowth from co-cultured CD4

Indexed as

CD4-Positive T-LymphocytesEpithelial CellsHIV-1HIV InfectionsInterleukinsIntestinal MucosaCoculture TechniquesGene Expression RegulationHumansTretinoinIL32 protein, humanInterleukinsTretinoinall-trans retinoic acidantiretroviral therapyCD4+ T-cellsCRISPR/Cas9HIV-1IL-22IL-26IL-32

Identifiers

PMID42273706
PMCPMC13247358

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.