Evidence mapPaperPMID 42274589Full record

ReviewCells2026

Systematic Methods to Resolve Lineage-Specific Stress States in Early Mammalian Embryos and That May Enable Miscarriage Prediction.

Ximena L Ruden, Campbell Coddington, Lynessa Asplund, Anjie Dinakin, Awoniyi O Awonuga, Douglas M Ruden, Steven J Korzeniewski, Lijun Zhang, Elizabeth E Puscheck, Daniel A Rappolee

Abstract readReview
In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ximena L RudenDepartment of Obstetrics and Gynecology, C. S. Mott Center for Human Growth and Development, Wayne State University, 275 East Hancock Street, Detroit, MI 48201, USA.ORCID 0000-0003-3674-7854
Campbell CoddingtonDepartment of Pharmaceutical Chemistry, University of California, San Diego, CA 92093, USA.
Lynessa AsplundDepartment of Obstetrics and Gynecology, C. S. Mott Center for Human Growth and Development, Wayne State University, 275 East Hancock Street, Detroit, MI 48201, USA.
Anjie DinakinDepartment of Obstetrics and Gynecology, C. S. Mott Center for Human Growth and Development, Wayne State University, 275 East Hancock Street, Detroit, MI 48201, USA.
Awoniyi O AwonugaDepartment of Obstetrics and Gynecology, C. S. Mott Center for Human Growth and Development, Wayne State University, 275 East Hancock Street, Detroit, MI 48201, USA.ORCID 0000-0002-0864-5394
Douglas M RudenDepartment of Obstetrics and Gynecology, C. S. Mott Center for Human Growth and Development, Wayne State University, 275 East Hancock Street, Detroit, MI 48201, USA.ORCID 0000-0002-0070-437X
Steven J KorzeniewskiDepartment of Obstetrics and Gynecology, C. S. Mott Center for Human Growth and Development, Wayne State University, 275 East Hancock Street, Detroit, MI 48201, USA.ORCID 0000-0002-8895-6052
Lijun ZhangDepartment of Population & Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.ORCID 0000-0003-4974-2745
Elizabeth E PuscheckDepartment of Obstetrics and Gynecology, C. S. Mott Center for Human Growth and Development, Wayne State University, 275 East Hancock Street, Detroit, MI 48201, USA.
Daniel A RappoleeDepartment of Obstetrics and Gynecology, C. S. Mott Center for Human Growth and Development, Wayne State University, 275 East Hancock Street, Detroit, MI 48201, USA.

Funding

NIEHS NIH HHS 1R41ES031451-01A1NIEHS NIH HHS 2P30ES020957-04
6 · The paper itself

Abstract

Early mammalian embryos are highly sensitive to environmental, metabolic, hormonal, and genomic stress, yet embryo assessment during

Indexed as

Cell LineageEmbryo, MammalianStress, PhysiologicalAnimalsBlastocystFemaleGene Expression ProfilingHumansPregnancyTranscriptomeTrophoblastsdevelopmental stem cellsdifferentially expressed gene (DEG)embryonic stem cells (ESCs)gene ontologyhigh-throughput screening (HTS)IC50LOAELmiscarriageNOAELstresssystematic stress classification and predictiontranscriptomic analysestrophoblast stem cells (TSCs)

Identifiers

PMID42274589
PMCPMC13256741

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.