ZONAB Regulates DNA Methylation, Mitochondrial Function, and Entry into Cell Senescence of Endothelial Cells.

Wenyi Jiang, Eleanor Lynam, Juliette Delafosse, Graeme M Birdsey, Anna M Randi, Karl Matter, Maria S Balda

Abstract read

In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenyi JiangUCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.

Eleanor LynamUCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.

Juliette DelafosseUCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.

Graeme M BirdseyNational Heart and Lung Institute (NHLI), Imperial College London, London W12 0NN, UK.ORCID 0000-0002-0981-8672

Anna M RandiNational Heart and Lung Institute (NHLI), Imperial College London, London W12 0NN, UK.

Karl MatterUCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.ORCID 0000-0001-8026-7220

Maria S BaldaUCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK.ORCID 0000-0002-8427-6746

Funding

BBSRC BB/X000575/1British Heart Foundation CRM:0001059Macular Disease Society 22-RG-3Moorfields Eye Charity R180018AMRC MR/W028735/1 and G0900098NIHR Biomedical Research Centre at Moorfields Eye Hospital NA

6 · The paper itself

Abstract

Regulation of the endothelial stress response is important for blood vessel homeostasis and angiogenesis, processes disrupted in common vascular diseases and ageing. Here, we discovered that the Y-box factor ZONAB (ZO-1-associated nucleic acid binding protein;

Indexed as

Cellular SenescenceDNA MethylationEndothelial CellsMitochondriaAngiogenesisAnimalsCell ProliferationHumansHuman Umbilical Vein Endothelial CellsOxidative StressProto-Oncogene Proteins c-aktReactive Oxygen SpeciesSignal TransductionProto-Oncogene Proteins c-aktReactive Oxygen Speciesangiogenesiscell cycleepigeneticmitochondriaoxidative phosphorylationoxidative stresssenescenceYBX3

Identifiers

PMID42274608

DOI10.3390/cells15111015

PMCPMC13256303

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.