Evidence map›Paper›PMID 42274767›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2026

Potentiating mild photothermal therapy via CDK12/13-mediated AKT suppression to orchestrate ferroptosis-apoptosis crosstalk for vaccine-like immunity.

Xi Pan, Wenlong Yang, Jueting Cai, Xiang Li, Mingyu Shi, Hui Guo, Weibi Wang, Junqi Zhang, Lingling Zhang

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Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xi PanDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, People's Republic of China.
Wenlong YangDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, People's Republic of China.
Jueting CaiDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, People's Republic of China.
Xiang LiDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, People's Republic of China.
Mingyu ShiDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, People's Republic of China.
Hui GuoDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, People's Republic of China.
Weibi WangDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, People's Republic of China.
Junqi ZhangDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, People's Republic of China.
Lingling ZhangDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, People's Republic of China. Zhanglingling206@163.com.

Funding

National Natural Science Foundation of China 82273172
6 · The paper itself

Abstract

backgroundMild photothermal therapy (MPTT) offers a safe thermal window but typically fails to trigger sufficient immunogenic inflammation for durable tumor control. Reprogramming the "cold" tumor microenvironment into a pro-inflammatory state is essential for effective immunotherapy.

methodsWe established a synchronized intervention strategy combining MPTT with CDK12/13 inhibition (SR4835) and TGF-β blockade (SB431542). We investigated the molecular crosstalk between ferroptosis and apoptosis and its impact on remodeling the tumor inflammatory landscape.

resultsMechanistically, MPTT intensified ROS-driven lipid peroxidation to potentiate ferroptosis, while SR4835 perturbed the CDK12/13-AKT axis to activate mitochondrial apoptosis. This synergy generated a robust pro-inflammatory immunogenic cell death (ICD) phenotype. Furthermore, TGF-β blockade dismantled immunosuppression, restoring the CD8⁺/Treg balance and fostering a pro-inflammatory cytokine milieu. Consequently, this regimen suppressed primary and distant tumors, reduced metastasis, and notably prevented tumor recurrence by activating memory T cells, thereby establishing durable vaccine-like immunity.

conclusionThese findings demonstrate that orchestrating ferroptosis-apoptosis crosstalk effectively reprograms the immune microenvironment. By repositioning MPTT from a local thermal tool to a driver of antitumor inflammation, this study establishes a mechanism-based framework for treating immunologically cold solid tumors.

Indexed as

Cyclin-Dependent KinasesFerroptosisProto-Oncogene Proteins c-aktAnimalsApoptosisCancer VaccinesCell Line, TumorFemaleHumansMiceMice, Inbred C57BLTransforming Growth Factor betaTumor MicroenvironmentCancer VaccinesCyclin-Dependent KinasesProto-Oncogene Proteins c-aktTransforming Growth Factor betaFerroptosis–apoptosis crosstalkImmunogenic inflammationMild photothermal therapy (MPTT)SR4835Systemic antitumor immunityTGF-β modulation

Identifiers

PMID42274767

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.