Evidence mapPaperPMID 42274769Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Alzheimer's disease-cancer research (inception to 2025): trends, themes, translational pathways, and insights from highly cited studies.

Manal Mohamed Elhassan Taha, Siddig Ibrahim Abdelwahab, Saeed Alshahrani, Abdulmajeed M Jali, Marwa Qadri, Abdulaziz Alarifi, Humaid Obaid Al-Shamsi

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Manal Mohamed Elhassan TahaHealth Research Centre, Jazan University, Jazan University, 45142, Jazan, Saudi Arabia.
Siddig Ibrahim AbdelwahabHealth Research Centre, Jazan University, Jazan University, 45142, Jazan, Saudi Arabia. siddigroa@yahoo.com.
Saeed AlshahraniDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, 45142, Jazan, Saudi Arabia.
Abdulmajeed M JaliDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, 45142, Jazan, Saudi Arabia.
Marwa QadriDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, 45142, Jazan, Saudi Arabia.
Abdulaziz AlarifiDepartment of Basic Sciences, College of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Humaid Obaid Al-ShamsiBurjeel Cancer Institute, Burjeel Medical City, P.O. Box 92510, Abu Dhabi, United Arab Emirates.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease-cancer research (ADCR) has gained increasing attention due to paradoxical epidemiological associations and shared yet oppositely regulated biological mechanisms; however, the field lacks an integrated synthesis of its intellectual and thematic structure. This study comprehensively mapped the longitudinal evolution, collaboration patterns, and conceptual architecture of ADCR. Scopus-indexed articles published between 1968 and 2025 were retrieved using a structured TITLE-ABS-KEY search strategy. Bibliometric indicators were analyzed using the Bibliometrix R package (Biblioshiny), and network, density, overlay, and thematic visualizations were generated using VOSviewer. Analyses included productivity trends, citation impact, collaboration networks, institutional and author performance, Bradford's and Lotka's laws, keyword co-occurrence, thematic evolution, and strategic mapping. The dataset comprised 7460 publications, with an annual growth rate of 11.98% and 24.79% international collaboration. Scientific output and citation impact were dominated by North America, Europe, and East Asia, led by the USA (2418 documents; 121,747 citations) and China (1406 documents; 40,410 citations). Thematically, Alzheimer's disease-centered neuroinflammatory mechanisms emerged as the principal motor theme, while cancer persisted as a foundational but less cohesive domain. Temporal analyses indicated a transition from early mechanistic fragmentation to consolidated interdisciplinary research, accompanied by the recent rise of molecular docking, machine learning, and network pharmacology. Collectively, ADCR is evolving into a mature, integrative field characterized by methodological innovation and growing translational convergence between neurodegeneration and oncology.

Indexed as

Alzheimer’s diseaseBibliometric analysisCancerMachine learningNeuroinflammation

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.