Evidence map›Paper›PMID 42275145›Full record

ArticleThe Journal of clinical investigation2026

Dietary omega-6 lipids promote postinjury aberrant bone formation in obesity.

Stefanie L Moye, Monisha Mittal, Tarun Srinivasan, Sneha Korlakunta, Chase A Pagani, Ayelet Dar, Oromo Geshow, Dylan Feist, Lauren G Zacharias, Zhao Li and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Stefanie L MoyeDepartment of Surgery.
Monisha MittalDepartment of Surgery.
Tarun SrinivasanMedical Scientist Training Program.
Sneha KorlakuntaDepartment of Surgery.
Chase A PaganiDepartment of Surgery.
Ayelet DarDepartment of Surgery.
Oromo GeshowDepartment of Surgery.
Dylan FeistDepartment of Surgery.
Lauren G ZachariasChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Zhao LiDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Aaron W JamesDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Gerta HoxhajChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Andrew M SmithDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Katherine A GallagherDepartment of Surgery and.
Thomas P MathewsChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Robert J TowerDepartment of Surgery.
Benjamin LeviDepartment of Surgery.

Funding

Targeting jmjd3 mitigates heterotopic ossificationR01AR079863 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Katherine Ann Gallagher, Benjamin Levi · 2021 to 2026
$3.0M
Neutrophil Biomarker and neutrophil targeted therapy to predict and prevent heterotopic ossificationR33AR078072 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI LEVI, BENJAMIN · 2023 to 2023
$410k
Dietary Interventions to Limit Heterotopic Ossification after Musculoskeletal InjuryF31AR086578 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI MOYE, STEFANIE · 2025 to 2025
$46k
NIAMS NIH HHS F31 AR086578NIAMS NIH HHS R01 AR079863NIAMS NIH HHS R33 AR078072
6 · The paper itself

Abstract

Obesity is associated with impaired wound healing, but the mechanisms linking excess adiposity to aberrant tissue repair remain unresolved. Heterotopic ossification (HO) is a severe example of pathologic tissue repair in which mesenchymal progenitor cells (MPCs) undergo aberrant osteochondral differentiation within soft tissue, leading to joint contractures and pain. Here, we show that accumulation of dietary omega-6 (ω-6) lipids in the injury site is a key mechanism linking obesity to HO. Specifically, in mice fed a high-fat diet (HFD), injured tissues were enriched in linoleic and arachidonic acids, providing substrate for myeloid COX-2-dependent prostaglandin E2 (PGE2) production. PGE2 then drove a transcriptional program in MPCs that promoted osteochondral differentiation. An isocaloric, low linoleic acid HFD reduced HO despite comparable obesity, demonstrating that dietary lipid composition, rather than adiposity alone, drove pathological repair. Clinical data mirrored these findings, showing that obesity conferred increased HO risk, and COX-2 inhibition reduced HO exclusively in obese patients. Together, these findings identify injury site ω-6 lipid enrichment as the key signal linking the diet to MPC reprogramming, pointing to dietary lipid modulation as an actionable strategy to limit HO in obesity.

Indexed as

Dietary FatsFatty Acids, Omega-6Mesenchymal Stem CellsObesityOssification, HeterotopicOsteogenesisAnimalsCyclooxygenase 2Diet, High-FatDinoprostoneHumansMaleMiceMice, Inbred C57BLCyclooxygenase 2Dietary FatsDinoprostoneFatty Acids, Omega-6Ptgs2 protein, mouseBone biologyBone diseaseInflammationInnate immunityMetabolismObesity

Identifiers

PMID42275145
PMCPMC13528920

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.