Evidence map›Paper›PMID 42275227›Full record

ArticleSTAR protocols2026

Protocol for direct in vivo evaluation of the stretch reflex in adult mice.

Travis M Rotterman, Caroline Casiano-Rivera, Paul Nardelli, T Richard Nichols, Francisco J Alvarez, Timothy C Cope

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Travis M RottermanDepartment of Pharmacology, Physiology, and Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA. Electronic address: trotter3@bu.edu.
Caroline Casiano-RiveraDepartment of Pharmacology, Physiology, and Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
Paul NardelliDepartment of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
T Richard NicholsDepartment of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Francisco J AlvarezDepartment of Cell Biology, Emory University, Atlanta, GA 30322, USA.
Timothy C CopeDepartment of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA; W.H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA 30332, USA.

Funding

DEVELOPMENT OF SYNAPTIC INPUTS ON SPINAL INTERNEURONSR01NS047357 · NINDS · WRIGHT STATE UNIVERSITY · PI ALVAREZ, FRANCISCO J · 2004 to 2025
$6.4M
Neuroinflammation Grading and Adjusting of Spinal Sensorimotor Circuitries in Response to Remote Injuries in Peripheral Nerves R01NS111969 · NINDS · EMORY UNIVERSITY · PI ALVAREZ, FRANCISCO J · 2020 to 2023
$1.5M
NINDS NIH HHS R01 NS047357NINDS NIH HHS R01 NS111969
6 · The paper itself

Abstract

Sensory feedback from muscle afferents that recruit spinal pathways is essential for coordination and stability. Dysregulation of these neural circuits may result in impaired coordinated motor behavior. Here, we present a protocol for assessing the stretch reflex in the adult decerebrate mouse. We describe steps for leg dissection, recording setup, decerebration, and reflex recording. This protocol can capture changes in muscle mechanics, sensory encoding, and ultimately muscle force generation under varying conditions. For complete details on the use and execution of this protocol, please refer to Rotterman et al.

Indexed as

Reflex, StretchAnimalsMiceMuscle, SkeletalBiotechnology and bioengineeringNeuroscienceSystems biology

Identifiers

PMID42275227
PMCPMC13276346

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.