ReviewCurrent opinion in structural biology2026
Spatial biology of crowded tumor cells: A new map for designing drug combinations.
Review in Current opinion in structural biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
2 authors.
Funding
Abstract
Understanding how tumor cells navigate crowded spatial environments to drive progression and how to deter them is challenging. Intracellularly, dynamic protein ensembles link genotype to phenotype. Dysregulation of these ensembles-driven by overexpression and mutational variants-alters the conformational landscapes, shifts cell states, and reshapes cell fate decisions. This diversity, spanning from the molecular level to the tumor microenvironment, triggers resistance mechanisms precipitating efforts to engineer effective combination strategies. Here, we underscore these transient cell states in migration and tissue adaptation, which depend on transcriptomic and signaling compatibility. Our spatial biology outlook envisions a map for designing drug combination strategies targeting both the primary tumor and disseminating cell states with host tissue commonalities, centering on bypass pathways to deter drug resistance and metastasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.