Evidence map›Paper›PMID 42277005›Full record

ArticleNature communications2026

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats.

Montana Kay Lara, Lieselot L G Carrette, Thiago Missfeldt Sanches, Oksana Polesskaya, Alicia Avelar, Angela Beeson, Hassiba Beldjoud, Brent Boomhower, Molly Brennan, Denghui Chen and 33 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

43 authors.

Montana Kay LaraDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-5810-4425
Lieselot L G CarretteDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-5217-2774
Thiago Missfeldt SanchesDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Oksana PolesskayaDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Alicia AvelarJamestown Community College, Olean, NY, USA.
Angela BeesonDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Hassiba BeldjoudDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Brent BoomhowerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Molly BrennanDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Denghui ChenDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-6541-3418
Riyan ChengDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Lindsey ChinaDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Apurva S ChitreDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Dana Elizabeth ConliskThe Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0002-4641-7878
McKenzie FannonDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Benjamin B JohnsonDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Elaine KeungDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Adam KimbroughPurdue University, West Lafayette, IN, USA.
Jenni KononoffThe Scripps Research Institute, La Jolla, CA, USA.
Angelica Renee MartinezDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Lisa MaturinDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Khai-Minh NguyenDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Alex MorganDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Joseph MosqueraDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Dyar OthmanDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Sonja L PlasilDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Jarryd RamborgerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Paul SchweitzerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Sharona SedighimDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Osborne SeshieDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Kokila ShankarDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Benjamin SichelDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Sierra SimpsonDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Lauren Cassandra SmithDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Elizabeth A SneddonDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Lani TieuDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Nathan VelardeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Selene ZahediDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0009-0008-8151-4850
Leah C Solberg WoodsDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-7943-798X
Marsida KallupiDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-8688-709X
Giordano de GuglielmoDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-4782-7430
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA. aap@ucsd.edu.ORCID 0000-0003-3634-0747
Olivier GeorgeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA. olgeorge@health.ucsd.edu.ORCID 0000-0002-3700-5003

Funding

Sequencing CoreP50DA037844 · NIDA · UNIVERSITY OF CHICAGO · PI PALMER, ABRAHAM A · 2014 to 2023
$27.4M
Identification of Genetic Variants that Contribute to Compulsive Cocaine Intakein RatsU01DA043799 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Olivier George, Abraham A Palmer · 2017 to 2026
$7.9M
DP30DA060810 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Oksana O Polesskaya · 2024 to 2026
$5.6M
The role of structural variants and tandem repeats in substance abuse-related behavioral traitsU01DA051234 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GYMREK, MELISSA, PALMER, ABRAHAM A · 2021 to 2025
$3.5M
U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30DA060810U.S. Department of Health & Human Services | National Institutes of Health (NIH) P50DA037844U.S. Department of Health & Human Services | National Institutes of Health (NIH) U01DA051234U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) U01DA043799
6 · The paper itself

Abstract

Cocaine use disorder (CUD) is a major public health crisis. The specific genes mediating CUD remain largely unknown. We conducted a genome-wide association study (GWAS) using outbred N/NIH Heterogeneous Stock (HS; n = 836, female = 415, male = 421) rats. We examined CUD-related phenotypes including acquisition of self-administration, escalation of intake, and compulsive-like responding. These traits were phenotypically correlated and exhibited modest SNP heritability (h

Indexed as

CocaineCocaine-Related DisordersGenome-Wide Association StudyAnimalsFemaleHumansLinkage DisequilibriumMalePhenotypePolymorphism, Single NucleotideRatsSelf AdministrationCocaine

Identifiers

PMID42277005
PMCPMC13261055

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.