ArticleNature communications2026
Bone-derived Osterix+ osteolineage cells are a source of tumor-promoting myofibroblastic cancer-associated fibroblasts in breast cancer.
Giulia Furesi, Carisa Zeng, Emily M Eul, Jennifer Zarrer, Deborah J Veis, Jiayu Ye, Vasilios A Morikis, Taylor Malachowski, Darya Khantakova, Alina Ulezko Antonova and 8 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
18 authors.
Giulia FuresiDepartment of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Emily M EulDepartment of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Jiayu YeDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Vasilios A MorikisDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Taylor MalachowskiDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Alina Ulezko AntonovaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MWashington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Wade Brown · 2000 to 2026
$30.8MResource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8MThe Role of the Osteoblast Secretome in Bone FormationP30AR057235 · NIAMS · WASHINGTON UNIVERSITY · PI SWARNKAR, GAURAV · 2009 to 2018
$5.7MNovel Regulators of Inflammatory Arthritis and Bone ErosionR01AR066551 · NIAMS · WASHINGTON UNIVERSITY · PI FACCIO, ROBERTA · 2015 to 2020
$2.0MRole of Bone in Primary and Metastatic CancerR01CA235096 · NCI · WASHINGTON UNIVERSITY · PI FACCIO, ROBERTA · 2020 to 2024
$1.8MRole of Osterix+ Osteolineage Cells in Primary and Metastatic Breast CancerR01CA270030 · NCI · WASHINGTON UNIVERSITY · PI Roberta Faccio · 2023 to 2026
$1.7MRegulation of hematopoiesis during tumor progressionF31CA284858 · NCI · WASHINGTON UNIVERSITY · PI EUL, EMILY M · 2023 to 2025
$146kAlternative NF-KB as a negative regulator of osteogenesisF31AR068853 · NIAMS · WASHINGTON UNIVERSITY · PI DAVIS, JENNIFER LYNN · 2015 to 2017
$91kNCI NIH HHS F31 CA284858NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA235096NCI NIH HHS R01 CA270030NIAMS NIH HHS F31 AR068853NIAMS NIH HHS P30 AR057235NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR066551NIDDK NIH HHS P30 DK052574U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA235096U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA270030U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR066551
6 · The paper itselfAbstract
Cancer-associated fibroblasts (CAFs) are major regulators of breast cancer (BC) progression and therapeutic resistance, yet the extent to which CAF heterogeneity is dictated by distinct cellular origins remains unresolved. Here, we identify bone-derived Osterix
Indexed as
Bone and BonesBreast NeoplasmsCancer-Associated FibroblastsMyofibroblastsSp7 Transcription FactorAnimalsCell DifferentiationCell Line, TumorExtracellular MatrixFemaleGene Expression Regulation, NeoplasticHumansMiceSP7 protein, humanSp7 protein, mouseSp7 Transcription Factor
Identifiers
PMID42277024
PMCPMC13408961
What Socratic holds
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LicenceCC BY
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