Evidence map›Paper›PMID 42277060›Full record

ArticleNature communications2026

Transferrin receptor 1 binds human parvovirus B19 VP1u to facilitate entry.

Hyunwook Lee, Jan Bieri, Nicolas Ammann, Corinne Suter, Daniela Hunziker, Ajit K Singh, Carol M Bator, Susan L Hafenstein, Carlos Ros

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hyunwook Lee *The Hormel Institute, University of Minnesota, Austin, MN, USA.ORCID http://orcid.org/0000-0002-5428-8594
Jan Bieri *Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland.
Nicolas AmmannDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland.
Corinne SuterDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland.
Daniela HunzikerDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland.
Ajit K SinghThe Hormel Institute, University of Minnesota, Austin, MN, USA.
Carol M BatorThe Hormel Institute, University of Minnesota, Austin, MN, USA.
Susan L HafensteinThe Hormel Institute, University of Minnesota, Austin, MN, USA. hafen@umn.edu.ORCID http://orcid.org/0000-0003-2609-4036
Carlos RosDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland. carlos.ros@unibe.ch.ORCID http://orcid.org/0000-0002-6964-4002

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 320030_207850
6 · The paper itself

Abstract

Human parvovirus B19 (B19V) displays a strict tropism for erythroid progenitor cells, which is governed by the VP1 unique domain (VP1u). This domain mediates cell-specific uptake through interaction with an unknown cellular receptor, termed VP1uR. Proximity labeling in permissive erythroid cells identifies transferrin receptor 1 (TfR1/CD71) as a predominant membrane protein associated with VP1u. VP1u constructs colocalize with TfR1 at the cell surface of erythroid cells. Incubation with anti-TfR1 antibody OKT9 abolishes binding and uptake of recombinant VP1u. While OKT9 efficiently inhibits B19V uptake and infection, it does not block virus binding to host cells. Direct binding assays confirm interaction of VP1u with human TfR1. Using cryo-EM we solved the 2.4 Å structure of the TfR1-VP1u complex, mapping the binding site. These findings establish TfR1 as the previously unknown receptor, VP1uR, required for B19V uptake.

Indexed as

Antigens, CDCapsid ProteinsParvovirus B19, HumanReceptors, TransferrinVirus InternalizationBinding SitesCryoelectron MicroscopyErythroid Precursor CellsHumansProtein BindingProtein DomainsReceptors, VirusAntigens, CDCapsid Proteinscapsid protein VP1, parvovirus B19CD71 antigenReceptors, TransferrinReceptors, Virus

Identifiers

PMID42277060
PMCPMC13408166

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.