Evidence map›Paper›PMID 42277431›Full record

ArticleNPJ cardiovascular health2026

Ex vivo heart perfusion induces time dependent inflammatory activation in human donor hearts.

Selena S Li, Bill Michaud, Asishana A Osho, David A D'Alessandro, Shannon N Tessier, Anthony Rosenzweig, S Alireza Rabi, James S Guseh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ cardiovascular health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Selena S LiDepartment of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Bill MichaudDepartment of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Asishana A OshoDivision of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
David A D'AlessandroDivision of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Shannon N TessierCenter for Engineering in Medicine and Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Anthony RosenzweigInstitute for Heart and Brain Health, University of Michigan, Ann Arbor, MI, USA.
S Alireza RabiDivision of Cardiovascular Surgery, University of Toronto, Toronto, Canada.
James S GusehCardiovascular Performance Program, Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. jguseh@mgb.org.

Funding

Institutional Career Development CoreKL2TR002542 · NCATS · HARVARD MEDICAL SCHOOL · PI BREDELLA, MIRIAM ANTOINETTE, RUTKOVE, SEWARD B. · 2018 to 2022
$8.7M
Pathways to Mentorship and Research: Training the Next Generation Physician-ScientistsR25AI147393 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2019 to 2024
$1.8M
American Heart Association Harold Amos Program (19AMFDP34990046),NCATS NIH HHS KL2 TR002542NIAID NIH HHS R25 AI147393NIH HHS R25 AI 147393 awardPresident and Fellows of Harvard College 5KL2TR002542-04Thoracic Surgery Foundation Nina Starr Braunwald Resident Research Award
6 · The paper itself

Abstract

Ex vivo heart perfusion (EVHP) has enabled the use of hearts donated after circulatory death (DCD), expanding the donor pool but with persistently higher rates of rejection and graft dysfunction. The molecular consequences of EVHP, however, remain incompletely defined. We quantified 11,083 proteins in perfusate from 20 human DCD hearts undergoing EVHP using an aptamer-based proteomic platform. Among the most strongly upregulated proteins were inflammatory cytokines IL-6 (log₂FC = 3.5, FDR = 8.9 × 10

Identifiers

PMID42277431
PMCPMC13639011

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.