Evidence map›Paper›PMID 42277433›Full record

ReviewNature cell biology2026

Proteomics-based insights into mammalian oocyte and early embryo development.

Sifan Rong, Zhuocheng Liu, Wencheng Zhu, Liangshan Mu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sifan Rong *Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Zhuocheng Liu *Shanghai Medical College, Fudan University, Shanghai, China.
Wencheng ZhuInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China. wzhu@szbl.ac.cn.ORCID http://orcid.org/0000-0001-8123-9504
Liangshan MuReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China. mu.liangshan@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0003-2498-3825

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82522038
6 · The paper itself

Abstract

Advances in proteomics are transforming our understanding of mammalian oocyte maturation and preimplantation embryo development. These resources and their findings provide unprecedented insights into the molecular underpinnings of developmental competence. Here we summarize the ongoing development of proteomic methodologies and highlight the stage-specific reprogramming events of the proteome in both humans and mice, underscoring the unique utility of proteomics in deciphering oocyte maturation and early embryonic development. Furthermore, we discuss the clinical implications of these findings, highlighting the translational potential of proteomics in understanding reproductive ageing, improving oocyte quality, and refining the outcomes of assisted reproductive technology.

Indexed as

Embryonic DevelopmentOocytesProteomicsAnimalsFemaleHumansMiceProteomeProteome

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.