ArticleBMC complementary medicine and therapies2026
Pistacia atlantica subsp. mutica essencial oil enhances proliferation and telomerase activity in senescent mesenchymal stem cells.
Article in BMC complementary medicine and therapies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAging impairs stem cell function, diminishing tissue regeneration. Dental pulp-derived mesenchymal stem cells (DPSCs) hold significant regenerative potential but are susceptible to senescence. Natural compounds like essential oils (EOs) offer low-toxicity strategies to enhance stem cell function. This study evaluated the in vitro senescence-modulating effects at the cellular level effects of Pistacia atlantica subsp. mutica green hull essential oil (PaEO) on senescent DPSCs. METHODS AND
resultsPaEO was extracted via hydrodistillation and characterized by GC-MS, identifying 22 major components (e.g., limonene, linalool, thymol, α/β-pinene). DPSCs were isolated from healthy third molars, cultured, and treated with varying PaEO concentrations. MTT assay and population doubling time (PDT) assessed viability and proliferation. Senescence-associated β-galactosidase (SA-β-gal) staining quantified senescent cells. Real-time PCR measured telomere-related genes (TRF1, RAP1). PaEO treatment significantly enhanced DPSC viability and proliferation dose-dependently. The highest concentration (1000 µg/mL) increased viability by 18% and reduced senescent cells (SA-β-gal positive) by 19.9%. Furthermore, PaEO upregulated the expression of TRF1 and RAP1 genes, indicating improved telomere maintenance and genomic stability.
conclusionPistacia atlantica subsp. mutica essential oil exhibits potent anti-senescence effects on DPSCs. It enhances cell viability and proliferation, reduces senescence markers, and modulates telomere-related gene expression. These findings suggest that PaEO exerts senescence-modulating effects at the cellular level in DPSCs. Further in vivo and clinical studies are warranted to validate these promising in vitro results.
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