ArticleWorld journal of surgical oncology2026
Regulation of miR-27a-3p/FBXW7 axis by increasing the level of lncRNA AC138128.1 to mitigate gastric cancer progression.
Article in World journal of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGastric cancer (GC) has a poor prognosis due to its recurrence and metastasis. This research aims to investigate the potential regulatory mechanisms of AC138128.1 in GC.
methodsA total of 124 GC patients were enrolled. RT-qPCR was used to assess AC138128.1, miR-27a-3p, and mRNA levels. Cell proliferation, migration, and invasion were assessed using CCK-8 and Transwell assays, respectively. Kaplan-Meier curves were used to validate patient survival. Targeted interactions among AC138128.1, miR-27a-3p, and FBXW7 were verified via DLR assays, with Pearson correlation analysis assessing relationships among the three groups. GO and KEGG were used to analyze the biological information of miR-27a-3p target genes.
resultsAC138128.1 is downregulated in GC tissues, miR-27a-3p level is upregulated. AC138128.1 negatively regulates miR-27a-3p. Patients with GC in the low AC138128.1 level group exhibited lower 5-year survival rates. Transfection with oe-AC138128.1 reduces miR-27a-3p levels, significantly inhibiting cell growth and invasiveness. However, when the miR-27a-3p level is increased, this inhibitory effect is reversed. Additionally, the downstream target genes of miR-27a-3p are primarily enriched in the PI3K-Akt signaling pathway. FBXW7 expression was downregulated in GC tissues. AC138128.1 expression positively correlated with FBXW7, whereas miR-27a-3p expression negatively correlated with FBXW7.
conclusionsThis study provides the first evidence that AC138128.1 is downregulated in GC cell lines and holds significant potential as a prognostic biomarker for GC. Low levels of AC138128.1 enhance miR-27a-3p expression, thereby influencing the invasiveness of GC cells and potentially promoting GC progression.
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