Modulation of NF-κB and TLR Signaling Pathways and Complement Components in Ovine Maternal Thyroid During Early Pregnancy.

Yaqi Zhang, Jingjing Li, Fei Yang, Chenxu Wu, Leying Zhang, Ling Yang

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yaqi ZhangSchool of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China.

Jingjing LiSchool of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China.

Fei YangSchool of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China.

Chenxu WuSchool of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China.

Leying ZhangSchool of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China.ORCID 0000-0002-8612-8325

Ling YangSchool of Life Sciences and Food Engineering, Hebei University of Engineering, Handan 056038, China.ORCID 0000-0003-4385-0024

Funding

Hebei Postgraduate Innovation Ability Funding Project CXZZSS2025087Hebei Provincial Department of Science and Technology C2024402023

6 · The paper itself

Abstract

Pregnancy modulates the function of the thyroid gland to facilitate maternal immune tolerance, and nuclear factor kappa B (NF-κB) subunits, the IκB family, and toll-like receptors (TLRs) and complement signaling pathways may be implicated in maternal thyroid immunoregulation. However, it is unclear whether early pregnancy modulates the expression of NF-κB subunits, the IκB family, TLRs, and complement components in the maternal thyroid. The objective of this study was to analyze the effects of early pregnancy on the expression of genes and proteins of these signaling pathways in the maternal thyroid in ewes. In this study, ovine thyroids (

Indexed as

Complement System ProteinsNF-kappa BSignal TransductionThyroid GlandToll-Like ReceptorsAnimalsFemaleGene Expression RegulationPregnancyRNA, MessengerSheepComplement System ProteinsNF-kappa BRNA, MessengerToll-Like Receptorseweimmune regulationIκB familyprotein and mRNA expressionthyroid function

Identifiers

PMID42278321

DOI10.3390/ijms27114791

PMCPMC13256796

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.