Evidence map›Paper›PMID 42278339›Full record

ArticleInternational journal of molecular sciences2026

Plasma Citrate Levels Are Inversely Associated with Estimated Muscle Mass and Strength in Liver Transplant Recipients.

Yakun Li, Adrian Post, Mateo Chvatal Medina, Caecilia S E Doorenbos, Margery A Connelly, Han Moshage, Stephan J L Bakker, Vincent E de Meijer, Robin P F Dullaart, TransplantLines Investigators

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yakun LiDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Adrian PostDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0001-8645-1627
Mateo Chvatal MedinaDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-4310-5657
Caecilia S E DoorenbosDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Margery A ConnellyLabcorp, 100 Perimeter Park, Morrisville, NC 27560, USA.ORCID 0000-0002-3917-592X
Han MoshageDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-4764-0246
Stephan J L BakkerDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-3356-6791
Vincent E de MeijerDepartment of Surgery, Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-7900-5917
Robin P F DullaartDepartment of Internal Medicine, Division of Endocrinology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-3844-5254
TransplantLines Investigators

Funding

Astellas Pharma (Netherlands) TransplantLines Biobank and Cohort studyChiesi Foundation PA-SP/PRJ-2020-9136DSM (Netherlands) project code: 14939Ministry of Economic Affairs and Climate Policy PPP-2019-032 and PPP-2022-015
6 · The paper itself

Abstract

Reduced muscle mass and strength are highly prevalent in liver transplant recipients (LTRs). Citrate, a key intermediate of the tricarboxylic acid cycle, may adversely relate to muscle health through disturbances in mitochondrial energy metabolism and metabolic flexibility. We aimed to investigate the association of plasma citrate levels with estimated muscle mass, strength, and physical performance in LTRs. We included stable LTRs from the TransplantLines Biobank and Cohort Study at least 1 year after transplantation. Muscle mass, strength, and physical performance were assessed using the 24 h urinary creatinine excretion rate divided by height squared (creatinine excretion rate index, CERI), handgrip strength, sit-to-stand (STS) and Timed Up and Go (TUG) tests. Associations of plasma citrate with muscle-related parameters were examined using Spearman correlation and linear regression analyses. A total of 501 LTRs were included (median age 59 [49-67] years; 58.7% men) at a median of 14.0 (7.4-22.5) years post-transplantation. Spearman correlation analyses showed that plasma citrate levels were inversely correlated with CERI (ρ= -0.226,

Indexed as

Citric AcidLiver TransplantationMuscle, SkeletalMuscle StrengthAgedFemaleHand StrengthHumansMaleMiddle AgedTransplant RecipientsCitric Acidcitrateliver transplantationliver transplant recipientsmitochondrial dysfunctionmuscle massmuscle strengthphysical performance

Identifiers

PMID42278339
PMCPMC13256401

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.