Evidence map›Paper›PMID 42278381›Full record

ReviewInternational journal of molecular sciences2026

Dihydrosanguinarine: A Review of Its Pharmacology, Structure-Activity Relationship, Toxicity, Pharmacokinetics, and Clinical Prospects.

Xiaoqi Yin, Yingyi Cao, Chuxuan Fang, Ce Zhang, Jiaming Yang, Mingyu Yu, Gong Cheng, Long Yang

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoqi YinSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Yingyi CaoNew Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.
Chuxuan FangSchool of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Ce ZhangSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Jiaming YangDepartment of Anatomy, School of Basic Medicine Sciences, Tianjin Medical University, Tianjin 300070, China.
Mingyu YuSchool of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Gong ChengNew Cornerstone Science Laboratory, Tsinghua University-Peking University Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China.
Long YangSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.ORCID 0009-0001-9293-1923

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dihydrosanguinarine (DHSA) is a naturally occurring benzo[c]phenanthridine alkaloid primarily isolated from plants of the Papaveraceae family. DHSA exhibits broad pharmacological activities, including antitumor, anti-inflammatory, hypoglycemic, neuroprotective, analgesic, anxiolytic, antiarrhythmic, and antimicrobial effects. Mechanistically, DHSA regulates multiple signaling pathways and molecular targets, including TMEM16A, p53, Ras/Raf/MEK/ERK, PI3K/AKT, NF-κB, PPARγ, GABA

Indexed as

BenzophenanthridinesIsoquinolinesAnimalsHumansSignal TransductionStructure-Activity RelationshipBenzophenanthridinesdihydrosanguinarineIsoquinolinesdihydrosanguinarinemolecular mechanismpharmacokineticspharmacological activitiesstructure–activity relationshiptoxicity

Identifiers

PMID42278381
PMCPMC13257051

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.