Evidence map›Paper›PMID 42278427›Full record

ArticleInternational journal of molecular sciences2026

Melatonin and Indole-3-Propionic Acid Reduce Surface FcγRIII/CD16-Related Parameters in Porcine Peripheral Blood Mononuclear Cells In Vitro.

Przemysław W Śliwka, Jan Stępniak, Małgorzata Karbownik-Lewińska

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Przemysław W ŚliwkaDepartment of Endocrinology and Metabolic Diseases, Medical University of Lodz, 281/289 Rzgowska St., 93-338 Lodz, Poland.
Jan StępniakDepartment of Endocrinology and Metabolic Diseases, Medical University of Lodz, 281/289 Rzgowska St., 93-338 Lodz, Poland.ORCID 0000-0002-7547-6228
Małgorzata Karbownik-LewińskaDepartment of Endocrinology and Metabolic Diseases, Medical University of Lodz, 281/289 Rzgowska St., 93-338 Lodz, Poland.ORCID 0000-0002-3045-5669

Funding

Medical University of Lodz 503/1-107-03/503-11-001
6 · The paper itself

Abstract

FcγRIII (CD16) is expressed by several leukocyte populations, including monocytes, macrophages, and natural killer cells, and plays an important role in IgG-mediated immune responses. Altered CD16 expression has been reported in inflammatory and autoimmune conditions, including thyroid-associated immune alterations. This preliminary in vitro study investigated whether the indole-derived compounds melatonin and indole-3-propionic acid (IPA) affect surface FcγRIII/CD16-related parameters in porcine peripheral blood mononuclear cells (PBMCs) cultured alone or with autologous thyroid follicular cells. PBMCs were left untreated or treated with melatonin or IPA, both at 50 µM, and analysed by flow cytometry at baseline and after 24 and 48 h of culture. The percentage of CD45

Indexed as

IndolesLeukocytes, MononuclearMelatoninReceptors, IgGAnimalsCells, CulturedCoculture TechniquesLeukocyte Common AntigensSwineIndolesLeukocyte Common AntigensMelatoninReceptors, IgGFcγRIII (CD16)indole-3-propionic acid (IPA)melatoninperipheral blood mononuclear cells (PBMCs)thyroid

Identifiers

PMID42278427
PMCPMC13257097

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.