Evidence map›Paper›PMID 42278429›Full record

ArticleInternational journal of molecular sciences2026

Integrating Metabolomics and Network Pharmacology to Reveal the Mechanism of Thymoquinone Alleviating Renal Interstitial Fibrosis in UUO Mice.

Yuanqing Liu, Huijing Zhang, Yanjun Dong, Gebin Li, Kai Fan, Zhihui Hao, Shuaiyu Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuanqing LiuCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Huijing ZhangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Yanjun DongCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Gebin LiCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Kai FanCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0000-0003-1934-7111
Zhihui HaoCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0000-0001-9516-6270
Shuaiyu WangCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

Funding

the National Natural Science Foundation of China 32172899
6 · The paper itself

Abstract

Chronic kidney disease (CKD) represents a considerable health burden for both humans and veterinary patients globally. Renal fibrosis is the final common pathway for the progression of CKD to end-stage renal disease, which can eventually lead to renal failure. Thymoquinone (TQ), the primary bioactive constituent of

Indexed as

BenzoquinonesKidney DiseasesMetabolomicsNetwork PharmacologyUreteral ObstructionAnimalsDisease Models, AnimalFibrosisKidneyMaleMiceMice, Inbred C57BLPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionBenzoquinonesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktthymoquinonechronic kidney diseasemetabolomicsnetwork pharmacologyPI3K/AKT signaling pathwayrenal interstitial fibrosisthymoquinoneunilateral ureteral obstruction

Identifiers

PMID42278429
PMCPMC13257271

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.