Evidence map›Paper›PMID 42278447›Full record

ArticleInternational journal of molecular sciences2026

Timing-Dependent Effects of Dexamethasone in a Mouse Model of Neonatal Hypoxic-Ischemic Brain Injury: A Transcriptomic Analysis of Synaptic Signaling and Calcium Homeostasis.

Joohee Lim, Jungho Han, Jeung Eun Shin, Kwangsoo Jung, Il-Sun Kim, Younhee Ko, Kook In Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joohee LimDepartment of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.ORCID 0000-0003-4376-6607
Jungho HanDepartment of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Jeung Eun ShinDepartment of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.ORCID 0000-0002-4376-8541
Kwangsoo JungResearch and Development Team, Radexel Inc., Seoul 04387, Republic of Korea.ORCID 0000-0001-7365-7247
Il-Sun KimDepartment of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Younhee KoDivision of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin 17035, Republic of Korea.ORCID 0000-0002-2843-2222
Kook In ParkDepartment of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The optimal timing and therapeutic role of dexamethasone for neuroprotection in neonatal hypoxic-ischemic (HI) brain injury remain unclear. We investigated whether dexamethasone-mediated neuroprotection is time-dependent and explored its underlying molecular mechanisms in a neonatal HI mouse model. The Rice-Vannucci model (unilateral carotid artery ligation followed by 8% O

Indexed as

CalciumDexamethasoneHypoxia-Ischemia, BrainNeuroprotective AgentsSynapsesTranscriptomeAnimalsAnimals, NewbornDisease Models, AnimalGene Expression ProfilingHomeostasisMaleMiceMice, Inbred C57BLCalciumDexamethasoneNeuroprotective Agentscalcium homeostasisdexamethasoneneonatal hypoxic–ischemic brain injuryneuroprotectionsynaptic signalingtranscriptomics

Identifiers

PMID42278447
PMCPMC13256103

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.