Evidence map›Paper›PMID 42278458›Full record

ArticleInternational journal of molecular sciences2026

Mitigation of Ischemia-Reperfusion Injury and Improvement in Overall Graft Viability by Hypothermic Pulsatile Perfusion with Molecular Hydrogen Is Associated with Trx-1/HO-1 Activation in a Non-Survival Ex Vivo Swine Model of Donation-After-Circulatory-Death Kidney Preservation and Transplantation.

George J Dugbartey, Cora England, Tamara S Ortas, Mahmoud Richard-Mohamed, Larry Jiang, Talal Shamma, Martin Igbokwe, Ali Bozaci, Juan Gonzalez Oyarzun, David Seok and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

George J DugbarteyMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.ORCID 0000-0001-8161-7202
Cora EnglandMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.
Tamara S OrtasMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.ORCID 0009-0002-8809-3821
Mahmoud Richard-MohamedDepartment of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.ORCID 0000-0001-5920-6511
Larry JiangDepartment of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.
Talal ShammaMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.
Martin IgbokweDepartment of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.ORCID 0000-0002-9155-3262
Ali BozaciDepartment of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.
Juan Gonzalez OyarzunDepartment of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.
David SeokDepartment of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.
Saeeda A ZainulDepartment of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.
Lori HarrowDepartment of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.
Monica FreemanDepartment of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.ORCID 0009-0007-3226-8246
Renee Lindo-AnuDepartment of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.ORCID 0009-0003-3426-8494
Aushanth RuthirakanthanDepartment of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.
Abdullah AlfaifiDepartment of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.
John WangDepartment of Physiology & Pharmacology, Western University, London, ON N6A 5C1, Canada.
Patrick McLeodMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.ORCID 0009-0004-6141-5098
Aaron HaigDepartment of Pathology, Schulich School of Medicine & Dentistry, University of Western, London, ON N6A 5C1, Canada.
Christopher BonhamDepartment of Biochemistry, Siebens-Drake Research Institute, Western University, London, ON N6A 5C1, Canada.
Alp SenerMatthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada.ORCID 0000-0002-8305-0876

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite their reduced viability, kidneys from donors-after-circulatory-death (DCD) increase the pool of transplantable kidneys. Molecular hydrogen (H

Indexed as

Graft SurvivalHeme Oxygenase-1HydrogenKidney TransplantationOrgan PreservationReperfusion InjuryAdenosineAllopurinolAnimalsCreatinineGlutathioneInsulinKidneyMaleOrgan Preservation SolutionsPerfusionAdenosineAllopurinolCreatinineGlutathioneHeme Oxygenase-1HydrogenInsulinOrgan Preservation SolutionsRaffinoseUniversity of Wisconsin-lactobionate solutiondonation-after-circulatory-death (DCD)hypothermic pulsatile perfusionischemia-reperfusion injury (IRI)kidney transplantationmolecular hydrogen (H2)

Identifiers

PMID42278458
PMCPMC13256565

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.