Primed Avian Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Restore Granulosa Cell Homeostasis in a CTX-Induced POI-like Dysfunction Model Under Human Menopausal Gonadotropin Stimulation.

Hsiang-Chun Dong, Kuo-Min Su, Chi-Kang Lin, Hui-Rong Cheng, Chih-Hsiang Yin, Fung-Wei Chang

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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2 · The registry

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5 · Who and what money

Authors and funding

6 authors.

Hsiang-Chun DongDepartment of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical University, Taipei 11490, Taiwan.ORCID 0000-0003-3642-3251

Kuo-Min SuDepartment of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical University, Taipei 11490, Taiwan.ORCID 0000-0001-7366-3671

Chi-Kang LinDepartment of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical University, Taipei 11490, Taiwan.

Hui-Rong ChengDepartment of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical University, Taipei 11490, Taiwan.

Chih-Hsiang YinDepartment of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical University, Taipei 11490, Taiwan.

Fung-Wei ChangDepartment of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical University, Taipei 11490, Taiwan.ORCID 0000-0002-5646-4889

Funding

Tri-Service General Hospital TSGH-D-114118Tri-Service General Hospital TSGH-D-115126Tri-Service General Hospital Penghu Branch TSGH-PH-E 115012

6 · The paper itself

Abstract

Premature ovarian insufficiency (POI) is a heterogeneous disorder, and cyclophosphamide (CTX)-induced ovarian injury represents an acquired POI-like condition rather than the full clinical spectrum of POI. In this study, CTX was used to establish a granulosa cell dysfunction model to evaluate whether primed avian mesenchymal stem cell-derived small extracellular vesicles (primed AMSC-sEVs) could restore granulosa cell homeostasis under human menopausal gonadotropin (hMG) stimulation, a clinically relevant gonadotropin context used in ovarian stimulation. Human granulosa cells were exposed to CTX and subsequently treated with hMG, naïve AMSC-sEVs, or primed AMSC-sEVs. Cell viability, mitochondrial membrane potential,

Indexed as

CyclophosphamideExtracellular VesiclesGonadotropinsGranulosa CellsMesenchymal Stem CellsPrimary Ovarian InsufficiencyAnimalsAnti-Mullerian HormoneCell SurvivalChickensFemaleHomeostasisHumansMembrane Potential, MitochondrialMitochondriaReceptors, FSHAnti-Mullerian HormoneCyclophosphamideGonadotropinsReceptors, FSHanti-Müllerian hormoneavian mesenchymal stem cellscyclophosphamide modelgranulosa cellshuman menopausal gonadotropinmitochondrial membrane potentialpremature ovarian insufficiencyprimed small extracellular vesicles

Identifiers

PMID42278460

DOI10.3390/ijms27114934

PMCPMC13257334

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.