Evidence map›Paper›PMID 42278494›Full record

ArticleInternational journal of molecular sciences2026

Poly(I:C) Lipoamino Bundle LNPs Induce Tumor Cytotoxicity and Immune Activation with Enhanced Efficacy by Survivin Silencing.

Mina Yazdi, Zahra Hasheminejad, Khouloud Hachani, Joyce Kache, Melina Grau, Barbara Wollenberg, Ali Bashiri Dezfouli, Ernst Wagner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mina YazdiPharmaceutical Biotechnology, Department of Pharmacy, Ludwig-Maximilians-Universität (LMU), 81377 Munich, Germany.
Zahra HasheminejadPharmaceutical Biotechnology, Department of Pharmacy, Ludwig-Maximilians-Universität (LMU), 81377 Munich, Germany.ORCID 0009-0001-8081-3671
Khouloud HachaniDepartment of Otolaryngology, Head and Neck Surgery, TUM School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0001-8424-3912
Joyce KacheDepartment of Otolaryngology, Head and Neck Surgery, TUM School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany.
Melina GrauPharmaceutical Biotechnology, Department of Pharmacy, Ludwig-Maximilians-Universität (LMU), 81377 Munich, Germany.
Barbara WollenbergDepartment of Otolaryngology, Head and Neck Surgery, TUM School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0002-3062-459X
Ali Bashiri DezfouliDepartment of Otolaryngology, Head and Neck Surgery, TUM School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany.
Ernst WagnerPharmaceutical Biotechnology, Department of Pharmacy, Ludwig-Maximilians-Universität (LMU), 81377 Munich, Germany.ORCID 0000-0001-8413-0934

Funding

BAYCELLator AZ-1568-22BMBF Cluster for Future 'CNATM - Cluster for Nucleic Acid Therapeutics Munich project-ID 03ZU1201AAGerman Research Foundation project-ID 201269156) sub-project B4
6 · The paper itself

Abstract

Synthetic polyinosinic:polycytidylic acid (poly(I:C)) offers an attractive cancer therapeutic by operating on two fronts at once, combining direct tumor cell killing with immunostimulatory activity. Yet, these dual functions can only be efficiently harnessed when intracellular delivery is sufficiently effective to enable poly(I:C) to reach and activate its intracellular receptors. We addressed this delivery challenge by developing pH-responsive formulations using lipoamino fatty acid xenopeptide (LAF-XP) carriers, composed of polar cationizable succinoyl tetraethylene pentamine (Stp) and apolar cationizable LAF building blocks in defined architectures. In particular, poly(I:C)-lipid nanoparticles (LNPs) formulated with bundle LAF

Indexed as

LipidsNanoparticlesPoly I-CSurvivinCell Line, TumorGene SilencingHumansLeukocytes, MononuclearRNA, Small InterferingBIRC5 protein, humanLipidsPoly I-CRNA, Small InterferingSurvivincancerlipid nanoparticleslipoamino fatty acidPBMCspoly(I:C)survivin

Identifiers

PMID42278494
PMCPMC13256650

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.