Evidence map›Paper›PMID 42278496›Full record

ArticleInternational journal of molecular sciences2026

Chitosan Oligosaccharides Suppress Adipogenesis and Lipid Accumulation in 3T3-L1 Preadipocytes via Multi-Pathway Transcriptomic Reprogramming.

Sineenart Songkoomkrong, Siriporn Nonkhwao, Jirawat Saetan, Supawadee Duangprom, Prateep Amonruttanapun, Piyapon Janpan, Prasert Sobhon, Napamanee Kornthong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sineenart SongkoomkrongChulabhorn International College of Medicine, Thammasat University, Rangsit Campus, Pathumthani 12120, Thailand.
Siriporn NonkhwaoChulabhorn International College of Medicine, Thammasat University, Rangsit Campus, Pathumthani 12120, Thailand.ORCID 0009-0007-4785-6251
Jirawat SaetanDivision of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Supawadee DuangpromChulabhorn International College of Medicine, Thammasat University, Rangsit Campus, Pathumthani 12120, Thailand.ORCID 0000-0002-6307-8986
Prateep AmonruttanapunChulabhorn International College of Medicine, Thammasat University, Rangsit Campus, Pathumthani 12120, Thailand.ORCID 0009-0007-1995-3003
Piyapon JanpanChulabhorn International College of Medicine, Thammasat University, Rangsit Campus, Pathumthani 12120, Thailand.
Prasert SobhonDepartment of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Napamanee KornthongChulabhorn International College of Medicine, Thammasat University, Rangsit Campus, Pathumthani 12120, Thailand.

Funding

Research Fund of Chulabhorn International College of Medicine, Thammasat University T1/2565Thailand Science Research and Innovation Fundamental Fund, fiscal year 2025Thammasat Postdoctoral Fellowship
6 · The paper itself

Abstract

Obesity is a major global health burden that is linked to type 2 diabetes, cardiovascular disease, and metabolic syndrome. Chitosan oligosaccharides (COS) are bioactive compounds that are derived from the depolymerization of the chitosan in crustacean shells and are promising candidates for natural anti-adipogenesis effects. However, there is incomplete understanding of the molecular mechanisms by which structurally defined low-molecular-weight COS modulates adipogenic transcription networks and global transcriptional reprogramming. MALDI-TOF (matrix-assisted laser desorption/ionization time-of-flight) mass spectrometry and

Indexed as

AdipocytesAdipogenesisChitosanLipid MetabolismOligosaccharidesTranscriptome3T3-L1 CellsAnimalsMicePPAR gammaSignal TransductionChitosanOligosaccharidesPPAR gamma3T3-L1 preadipocytesadipogenesischitosan oligosaccharides (COS)lipid accumulationtranscriptomics

Identifiers

PMID42278496
PMCPMC13256913

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.