Evidence map›Paper›PMID 42278497›Full record

ArticleInternational journal of molecular sciences2026

Age-Related Platelet Cox-1 Upregulation in Atrial Fibrillation.

Emanuele Valeriani, Vittoria Cammisotto, Danilo Menichelli, Daniele Pastori, Valentina Castellani, Simona Bartimoccia, Giovanni Cucchiara, Arianna Pannunzio, Ilaria Maria Palumbo, Ombretta Martinelli and 3 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emanuele ValerianiDepartment of Internal Medicine, Endocrine and Metabolic Sciences, and Infectious Diseases, Azienda Ospedaliero-Universitaria Policlinico Umberto I, 00161 Rome, Italy.ORCID 0000-0001-9729-3214
Vittoria CammisottoDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-1966-5945
Danilo MenichelliDepartment of General Surgery and Surgical Specialty, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-9467-5903
Daniele PastoriDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-6357-5213
Valentina CastellaniDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-6455-4828
Simona BartimocciaDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-6266-3059
Giovanni CucchiaraInternal Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Arianna PannunzioDepartment of General Surgery and Surgical Specialty, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-4901-7626
Ilaria Maria PalumboDepartment of General Surgery and Surgical Specialty, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0009-0008-5749-786X
Ombretta MartinelliDepartment of Surgery "Paride Stefanini"-Policlinico Umberto I, Vascular Surgery Division, Sapienza University of Rome, 00161 Rome, Italy.
Roberto CarnevaleScientific Institute for Research, Hospitalization and Healthcare IRCCS Neuromed, 86077 Pozzilli, Italy.ORCID 0000-0002-6216-9595
Francesco VioliDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Pasquale PignatelliDepartment of Medical and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-2265-7455

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is associated with enhanced platelet activation that may contribute to the occurrence of cardiovascular events. However, the mechanism linking aging with platelet activation is not fully understood. The objective of this study is to investigate the relationship between aging, platelet Cox-1 expression, and thromboxane (Tx) B2 production in patients with atrial fibrillation. Serum Cox-1 and TxB2 were measured in 134 patients with atrial fibrillation. Correlations were assessed between age, Cox-1, and TxB2. A robust mediation analysis evaluated whether Cox-1 mediates the association between age and TxB2. In vitro experiments were performed in 20 patients to evaluate the effect of aspirin on platelet TxB2 production and to quantify platelet Cox-1 expression across age groups (i.e., < or ≥65 years). Serum Cox-1 and TxB2 progressively increased by decades of age. A positive and significant correlation was found between age and Cox-1 (R = 0.42,

Indexed as

AgingAtrial FibrillationBlood PlateletsCyclooxygenase 1Up-RegulationAdultAgedAged, 80 and overAge FactorsAspirinFemaleHumansMaleMiddle AgedThromboxane B2AspirinCyclooxygenase 1PTGS1 protein, humanThromboxane B2agingaspirinatrial fibrillationcyclooxygenase 1thromboxane

Identifiers

PMID42278497
PMCPMC13256525

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.